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Reversal of T-cell tolerance in myelodysplastic syndrome through lenalidomide immune modulation.

作者信息

McDaniel J M, Zou J X, Fulp W, Chen D-T, List A F, Epling-Burnette P K

出版信息

Leukemia. 2012 Jun;26(6):1425-9. doi: 10.1038/leu.2011.359. Epub 2011 Dec 23.

DOI:10.1038/leu.2011.359
PMID:22193963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3321111/
Abstract
摘要

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Lenalidomide enhances antigen-specific activity and decreases CD45RA expression of T cells from patients with multiple myeloma.来那度胺增强多发性骨髓瘤患者 T 细胞的抗原特异性活性并降低其 CD45RA 表达。
J Immunol. 2011 Jul 15;187(2):1047-56. doi: 10.4049/jimmunol.1002460. Epub 2011 Jun 15.
2
Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma.来那度胺和泊马度胺对多发性骨髓瘤肿瘤细胞与骨髓辅助细胞相互作用的免疫调节作用。
Blood. 2010 Oct 28;116(17):3227-37. doi: 10.1182/blood-2010-04-279893. Epub 2010 Jul 22.
3
A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide.
诱导化疗后早期淋巴细胞恢复时使用泊马度胺进行免疫调节治疗新诊断的 AML 和高危 MDS。
Leukemia. 2020 Jun;34(6):1563-1576. doi: 10.1038/s41375-019-0693-4. Epub 2020 Jan 3.
4
Deep sequencing of bone marrow microenvironments of patients with del(5q) myelodysplastic syndrome reveals imprints of antigenic selection as well as generation of novel T-cell clusters as a response pattern to lenalidomide.对伴有 del(5q)骨髓增生异常综合征患者骨髓微环境进行深度测序,揭示了免疫原性选择的痕迹,以及作为来那度胺反应模式产生新的 T 细胞簇。
Haematologica. 2019 Jul;104(7):1355-1364. doi: 10.3324/haematol.2018.208223. Epub 2019 Jan 17.
5
Pilot trial of K562/GM-CSF whole-cell vaccination in MDS patients.K562/GM-CSF全细胞疫苗在骨髓增生异常综合征患者中的初步试验。
Leuk Lymphoma. 2018 Dec;59(12):2801-2811. doi: 10.1080/10428194.2018.1443449. Epub 2018 Apr 4.
6
Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon.配体介导的蛋白降解揭示了 CUL4 型 E3 连接酶底物受体 cereblon 序列变异体之间的功能保守性。
J Biol Chem. 2018 Apr 20;293(16):6187-6200. doi: 10.1074/jbc.M117.816868. Epub 2018 Feb 15.
7
Lenalidomide-mediated erythroid improvement in non-del(5q) myelodysplastic syndromes is associated with bone marrow immuno-remodeling.来那度胺介导的非5q缺失型骨髓增生异常综合征红系改善与骨髓免疫重塑相关。
Leukemia. 2018 Feb;32(2):558-562. doi: 10.1038/leu.2017.305. Epub 2017 Oct 3.
8
Is There a Role for Flow Cytometry in the Evaluation of Patients With Myelodysplastic Syndromes?流式细胞术在骨髓增生异常综合征患者评估中是否具有作用?
Curr Hematol Malig Rep. 2015 Sep;10(3):309-17. doi: 10.1007/s11899-015-0272-3.
9
Treatment with lenalidomide induces immunoactivating and counter-regulatory immunosuppressive changes in myeloma patients.来那度胺治疗可诱导骨髓瘤患者产生免疫激活和免疫抑制的负向调节变化。
Clin Exp Immunol. 2014 Aug;177(2):439-53. doi: 10.1111/cei.12343.
10
Naive T-cells in myelodysplastic syndrome display intrinsic human telomerase reverse transcriptase (hTERT) deficiency.骨髓增生异常综合征中的幼稚 T 细胞表现出内在的人端粒酶逆转录酶(hTERT)缺陷。
Leukemia. 2013 Apr;27(4):897-906. doi: 10.1038/leu.2012.300. Epub 2012 Oct 17.
磷酸酶单倍体不足在来那度胺对5q缺失型骨髓增生异常综合征的选择性抑制中起关键作用。
Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12974-9. doi: 10.1073/pnas.0811267106. Epub 2009 May 26.
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Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug.慢性淋巴细胞白血病T细胞表现出免疫突触形成受损,而这可以通过一种免疫调节药物逆转。
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Epidemiology of myelodysplastic syndromes and chronic myeloproliferative disorders in the United States, 2001-2004, using data from the NAACCR and SEER programs.利用北美癌症登记协会(NAACCR)和监测、流行病学与最终结果(SEER)项目的数据,对2001 - 2004年美国骨髓增生异常综合征和慢性骨髓增殖性疾病的流行病学进行研究。
Blood. 2008 Jul 1;112(1):45-52. doi: 10.1182/blood-2008-01-134858. Epub 2008 Apr 28.
6
An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome.红系分化特征可预测骨髓增生异常综合征对来那度胺的反应。
PLoS Med. 2008 Feb;5(2):e35. doi: 10.1371/journal.pmed.0050035.
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T cell subset-specific susceptibility to aging.T细胞亚群对衰老的特异性易感性。
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Efficacy of lenalidomide in myelodysplastic syndromes.来那度胺在骨髓增生异常综合征中的疗效。
N Engl J Med. 2005 Feb 10;352(6):549-57. doi: 10.1056/NEJMoa041668.
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Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo.白细胞介素-7在体内介导初始和记忆性CD8 T细胞的稳态。
Nat Immunol. 2000 Nov;1(5):426-32. doi: 10.1038/80868.
10
Thymic aging and T-cell regeneration.胸腺衰老与T细胞再生。
Immunol Rev. 1997 Dec;160:91-102. doi: 10.1111/j.1600-065x.1997.tb01030.x.