细胞程序性坏死使 TNF 具有细胞毒性。
Necroptosis turns TNF lethal.
机构信息
INSERM, U848, Villejuif, F-94805, France.
出版信息
Immunity. 2011 Dec 23;35(6):849-51. doi: 10.1016/j.immuni.2011.12.004.
PMID:22195740
Abstract
In this issue of Immunity, Duprez et al. (2011) demonstrate that necroptosis, a form of regulated necrosis that is mediated by the kinases RIPK1 and RIPK3, underlies the lethal effects of tumor necrosis factor in vivo.
摘要
在本期《免疫》中，Duprez 等人（2011 年）证明，由激酶 RIPK1 和 RIPK3 介导的程序性细胞坏死形式——细胞坏死性凋亡，是肿瘤坏死因子在体内产生致死效应的基础。
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