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淋巴结中存在病毒储存库,会导致接受联合抗逆转录病毒疗法的 SIV 感染猕猴在停止治疗后血浆病毒血症反弹。

Lymph nodes harbor viral reservoirs that cause rebound of plasma viremia in SIV-infected macaques upon cessation of combined antiretroviral therapy.

机构信息

Laboratory of Primate Model, Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan.

出版信息

Virology. 2012 Feb 20;423(2):107-18. doi: 10.1016/j.virol.2011.11.024. Epub 2011 Dec 21.

Abstract

Attempts to find a cure for HIV infection are hindered by the presence of viral reservoirs that resist highly active antiretroviral therapy. To identify the properties of these reservoirs, four SIV239-infected Rhesus macaques were treated with combined antiretroviral therapy (cART) for 1 year. While plasma viral RNA (vRNA) was effectively suppressed, a systemic analysis revealed that vRNA was distributed in the following order: lymphatic tissues>lungs and intestine>other tissues. Histochemistry yielded no cells with viral signals. To increase the chance of detection, two additional SIV-infected animals were treated and analyzed on Day 10 after the cessation of cART. These animals exhibited similar vRNA distribution patterns to the former animals, and immunohistochemistry revealed Nef-positive T lymphocytes predominantly in the follicles of mesenteric lymph nodes (MLNs). These data suggest that lymphatic tissues, including MLNs, contain major cellular reservoirs that cause rebound of plasma viremia upon cessation of therapy.

摘要

试图寻找治愈 HIV 感染的方法受到存在抵抗高效抗逆转录病毒治疗的病毒库的阻碍。为了确定这些病毒库的特性,用联合抗逆转录病毒疗法(cART)对 4 只 SIV239 感染的恒河猴治疗 1 年。虽然血浆病毒 RNA(vRNA)得到有效抑制,但系统分析显示 vRNA 分布如下:淋巴组织>肺和肠道>其他组织。组织化学未发现带有病毒信号的细胞。为了增加检测机会,对另外 2 只 SIV 感染动物在 cART 停止后第 10 天进行治疗和分析。这些动物表现出与前一组动物相似的 vRNA 分布模式,免疫组化显示 Nef 阳性 T 淋巴细胞主要存在于肠系膜淋巴结(MLN)的滤泡中。这些数据表明,包括 MLN 在内的淋巴组织含有主要的细胞病毒库,这些病毒库会导致治疗停止后血浆病毒血症的反弹。

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