用于 siRNA 递送的基质系统。
Matrix systems for siRNA delivery.
机构信息
Laboratory of General Biochemistry and Physical Pharmacy, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium.
出版信息
Curr Top Med Chem. 2012;12(2):89-96. doi: 10.2174/156802612798919150.
Over the last decade, considerable effort has been put in the implementation of RNA interference (RNAi) as a treatment for various disorders. As RNAi occurs in the cytoplasm of cells, it is imperative that RNAi mediators such as small interfering RNA (siRNA) cross several extracellular and intracellular barriers to reach this site of action. Among the extensive range of proposed delivery systems for siRNA, matrix systems possess interesting properties to promote the delivery of siRNA to a target tissue. In this review, a number of recently developed matrix and hybrid systems for siRNA delivery are discussed.
在过去的十年中，人们投入了大量的精力来将 RNA 干扰 (RNAi) 作为治疗各种疾病的方法付诸实践。由于 RNAi 发生在细胞的细胞质中，因此 RNAi 调节剂（如小干扰 RNA (siRNA)）必须穿过多个细胞外和细胞内的屏障才能到达作用部位。在众多提出的 siRNA 递送系统中，基质系统具有促进 siRNA 递送到靶组织的有趣特性。在这篇综述中，讨论了一些最近开发的用于 siRNA 递送的基质和杂化系统。
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