Department of Pediatrics, Antalya Education and Research Hospital, Antalya, Turkey.
Pediatr Neurol. 2012 Jan;46(1):36-8. doi: 10.1016/j.pediatrneurol.2011.10.008.
Febrile seizures comprise a common type of pediatric convulsion. Inflammation and genetics may be involved in their pathogenesis. Regarding the role of cytokines (especially interleukin-6) in febrile responses, we performed a case control study of interleukin-6 gene (-174, -572, and -597) single-nucleotide polymorphisms to learn if correlations existed between these particular polymorphisms and febrile seizures. We isolated the genomic DNA of 92 children with febrile seizures and 98 healthy control subjects. We genotyped individuals for their polymorphisms, using polymerase chain reaction-restriction fragment length polymorphism. In our study, the frequencies of -174 G alleles and of the -174 and -572 GG genotypes were observed to be significantly higher in patients than in control subjects. The -174 GG genotype frequency was significantly higher in children with a family history of febrile seizures.
热性惊厥是一种常见的儿童惊厥类型。炎症和遗传可能与热性惊厥的发病机制有关。关于细胞因子（特别是白细胞介素-6）在发热反应中的作用，我们进行了一项白细胞介素-6 基因（-174、-572 和-597）单核苷酸多态性的病例对照研究，以了解这些特定多态性与热性惊厥之间是否存在相关性。我们从 92 名热性惊厥患儿和 98 名健康对照中分离出基因组 DNA。我们使用聚合酶链反应-限制性片段长度多态性对个体进行基因分型。在我们的研究中，与对照组相比，患者中-174 G 等位基因和-174 和-572 GG 基因型的频率明显更高。有热性惊厥家族史的儿童中-174 GG 基因型频率明显更高。
