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认知疗法可改善住院心力衰竭患者的三个月预后。

Cognitive therapy improves three-month outcomes in hospitalized patients with heart failure.

机构信息

University of Kentucky College of Nursing, Lexington, KY 40536-0232, USA.

出版信息

J Card Fail. 2012 Jan;18(1):10-20. doi: 10.1016/j.cardfail.2011.09.008. Epub 2011 Nov 9.

Abstract

BACKGROUND

Patients with heart failure (HF) experience depressive symptoms that contribute to poorer outcomes. We tested the effects of a brief cognitive therapy intervention on depressive symptoms, negative thinking, health-related quality of life, and cardiac event-free survival.

METHODS AND RESULTS

Hospitalized patients with depressive symptoms (n = 41, 66 ± 11 years, 45% female, 81% New York Heart Association Class III/IV) were randomly assigned to control group or a brief, nurse-delivered cognitive therapy intervention, delivered during hospitalization and followed by a 1-week booster phone call. Depressive symptoms, negative thinking, and health-related quality of life were measured at 1 week and 3 months. Cardiac event-free survival was assessed at 3 months. Mixed models repeated measures analysis of variance, Kaplan-Meier, and Cox regression were used for data analysis. There were significant improvements in depressive symptoms and health-related quality of life in both groups but no interactions between group and time. The control group had shorter 3-month cardiac event-free survival (40% versus 80%, P < .05) and a 3.5 greater hazard of experiencing a cardiac event (P = .04) than the intervention group.

CONCLUSION

Nurses can deliver a brief intervention to hospitalized patients with heart failure that may improve short-term, event-free survival. Future research is needed to verify these results with a larger sample size.

摘要

背景

心力衰竭(HF)患者会出现抑郁症状,从而导致预后更差。我们测试了一种简短的认知疗法干预对抑郁症状、消极思维、健康相关生活质量和无心脏事件生存的影响。

方法和结果

住院伴有抑郁症状的患者(n=41,66±11 岁,45%女性,81%纽约心脏协会 III/IV 级)被随机分配到对照组或简短的、由护士提供的认知疗法干预组,在住院期间和随后的 1 周电话强化治疗期间进行。在 1 周和 3 个月时测量抑郁症状、消极思维和健康相关生活质量。在 3 个月时评估无心脏事件生存。使用混合模型重复测量方差分析、Kaplan-Meier 和 Cox 回归进行数据分析。两组的抑郁症状和健康相关生活质量均有显著改善,但组间与时间无交互作用。对照组的 3 个月无心脏事件生存率(40%对 80%,P<.05)和经历心脏事件的风险增加 3.5 倍(P=0.04)均低于干预组。

结论

护士可以为住院心力衰竭患者提供一种简短的干预措施,可能会改善短期、无事件的生存。需要更大的样本量来验证这些结果。

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