Rajabi Soodeh, Shamsizadeh Ali, Amini Hossein, Shirazi Mohsen, Allahtavakoli Mohammad, Abbasnejad Mehdi, Sheibani Vahid
Kerman Neuroscience Research Centre, Kerman University of Medical Sciences, Iran.
Neurol Res. 2012 Jan;34(1):80-4. doi: 10.1179/1743132811Y.0000000050.
There is general agreement that norepinephrine could modulate neuronal responses to non-monoaminergic synaptic inputs in the somatosensory cortex. In the present study, we investigated the effect of central norepinephrine depletion on tactile learning in rats.
Central norepinephrine depletion was induced using 50 mg/kg of N-(2-chloroethyl)-N-ethyl-2 bromobenzylamine (DSP-4) and verified by high performance liquid chromatography. Memory performance was assessed 1 and 5 weeks after DSP-4 treatment using novel object recognition test.
We observed a learning impairment in both DSP-4 groups, as the preference index was not significantly altered when compared to chance level (50%).
These findings suggest that depletion of central norepinephrine by DSP-4 leads to impairment of the tactile learning in rats, which can last at least for 35 days.
人们普遍认为去甲肾上腺素可以调节体感皮层中神经元对非单胺能突触输入的反应。在本研究中，我们调查了中枢去甲肾上腺素耗竭对大鼠触觉学习的影响。
使用50mg/kg的N-(2-氯乙基)-N-乙基-2-溴苄胺（DSP-4）诱导中枢去甲肾上腺素耗竭，并通过高效液相色谱法进行验证。在DSP-4处理后1周和5周，使用新颖物体识别测试评估记忆表现。
我们在两个DSP-4组中均观察到学习障碍，因为与机遇水平（50%）相比，偏好指数没有显著变化。
这些发现表明，DSP-4导致的中枢去甲肾上腺素耗竭会导致大鼠触觉学习受损，这种损害至少可持续35天。
