Institute of the Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, Butlerova str., 5A, Moscow, 117485, Russia.
Brain Res. 2012 Feb 3;1436:147-56. doi: 10.1016/j.brainres.2011.12.006. Epub 2011 Dec 9.
Spike-wave discharges (SWD) are electroencephalographic hallmarks of absence epilepsy. SWD are known to originate from thalamo-cortical neuronal network that normally produces sleep spindle oscillations. Although sleep spindles and SWD are considered as thalamo-cortical oscillations, functional relationship between them is not obvious. The present study describes temporal dynamics of SWD and sleep spindles as determined in 24h EEG recorded in WAG/Rij rat model of absence epilepsy. SWD, sleep spindles (10-15 Hz) and 5-9 Hz oscillations were automatically detected in EEG using wavelet-based algorithm. It was found that non-linear dynamics of SWD fitted well to the law of 'on-off intermittency'. Sleep spindles also demonstrated 'on-off intermittency', in contrast to 5-9 Hz oscillations, whose dynamics could not be classified as having any known type of non-linear behavior. Intermittency in sleep spindles and SWD implies that (1) temporal dynamics of these oscillations are deterministic in nature, and (2) it might be controlled by a system-level mechanism responsible for circadian modulation of neuronal network activity.
棘波放电(SWD)是失神性癫痫的脑电图特征。已知 SWD 起源于丘脑-皮层神经元网络,该网络通常产生睡眠纺锤波振荡。尽管睡眠纺锤波和 SWD 被认为是丘脑-皮层振荡,但它们之间的功能关系并不明显。本研究描述了在 WAG/Rij 大鼠失神性癫痫模型中记录的 24 小时脑电图中确定的 SWD 和睡眠纺锤波的时间动力学。使用基于小波的算法在 EEG 中自动检测 SWD、睡眠纺锤波(10-15 Hz)和 5-9 Hz 振荡。结果发现,SWD 的非线性动力学很好地符合“开-关间歇性”定律。睡眠纺锤波也表现出“开-关间歇性”,而 5-9 Hz 振荡则不能归类为具有任何已知类型的非线性行为。睡眠纺锤波和 SWD 的间歇性表明:(1)这些振荡的时间动力学本质上是确定性的,(2)它可能由负责神经元网络活动的昼夜节律调制的系统级机制控制。