Suppr超能文献

具有遗传性失神癫痫倾向的大鼠脑电图中的丘脑-皮质振荡的开-关间歇性。

On-off intermittency of thalamo-cortical oscillations in the electroencephalogram of rats with genetic predisposition to absence epilepsy.

机构信息

Institute of the Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, Butlerova str., 5A, Moscow, 117485, Russia.

出版信息

Brain Res. 2012 Feb 3;1436:147-56. doi: 10.1016/j.brainres.2011.12.006. Epub 2011 Dec 9.

Abstract

Spike-wave discharges (SWD) are electroencephalographic hallmarks of absence epilepsy. SWD are known to originate from thalamo-cortical neuronal network that normally produces sleep spindle oscillations. Although sleep spindles and SWD are considered as thalamo-cortical oscillations, functional relationship between them is not obvious. The present study describes temporal dynamics of SWD and sleep spindles as determined in 24h EEG recorded in WAG/Rij rat model of absence epilepsy. SWD, sleep spindles (10-15 Hz) and 5-9 Hz oscillations were automatically detected in EEG using wavelet-based algorithm. It was found that non-linear dynamics of SWD fitted well to the law of 'on-off intermittency'. Sleep spindles also demonstrated 'on-off intermittency', in contrast to 5-9 Hz oscillations, whose dynamics could not be classified as having any known type of non-linear behavior. Intermittency in sleep spindles and SWD implies that (1) temporal dynamics of these oscillations are deterministic in nature, and (2) it might be controlled by a system-level mechanism responsible for circadian modulation of neuronal network activity.

摘要

棘波放电(SWD)是失神性癫痫的脑电图特征。已知 SWD 起源于丘脑-皮层神经元网络,该网络通常产生睡眠纺锤波振荡。尽管睡眠纺锤波和 SWD 被认为是丘脑-皮层振荡,但它们之间的功能关系并不明显。本研究描述了在 WAG/Rij 大鼠失神性癫痫模型中记录的 24 小时脑电图中确定的 SWD 和睡眠纺锤波的时间动力学。使用基于小波的算法在 EEG 中自动检测 SWD、睡眠纺锤波(10-15 Hz)和 5-9 Hz 振荡。结果发现,SWD 的非线性动力学很好地符合“开-关间歇性”定律。睡眠纺锤波也表现出“开-关间歇性”,而 5-9 Hz 振荡则不能归类为具有任何已知类型的非线性行为。睡眠纺锤波和 SWD 的间歇性表明:(1)这些振荡的时间动力学本质上是确定性的,(2)它可能由负责神经元网络活动的昼夜节律调制的系统级机制控制。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验