Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Vascul Pharmacol. 2012 Jan-Feb;56(1-2):34-46. doi: 10.1016/j.vph.2011.12.004. Epub 2011 Dec 16.
The vessel wall is no longer considered as only an anatomical barrier for blood cells but is recognized as an active endocrine organ. Dysfunction of the vessel wall occurs in various disease processes including atherosclerosis, hypertension, peripheral artery disease, aneurysms, and transplant and diabetic vasculopathies. Different cytokines were shown to modulate the behavior of the cells, which constitute the vessel wall such as immune cells, endothelial cells and smooth muscle cells. Glycoprotein 130 (gp130) is a common cytokine receptor that controls the activity of a group of cytokines, namely, interleukin (IL)-6, oncostatin M (OSM), IL-11, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC), IL-27, and neuropoietin (NP). Gp130 and associated cytokines have abundantly diverse functions. Part I of this review focuses on the pathophysiological functions of gp130 ligands. We specifically describe vascular effects of these molecules and discuss the respective underlying molecular and cellular mechanisms.
血管壁不再被仅仅视为血细胞的解剖学屏障，而是被认为是一个活跃的内分泌器官。血管壁功能障碍发生在多种疾病过程中，包括动脉粥样硬化、高血压、外周动脉疾病、动脉瘤以及移植和糖尿病血管病变。不同的细胞因子被证明可以调节构成血管壁的细胞的行为，如免疫细胞、内皮细胞和平滑肌细胞。糖蛋白 130（gp130）是一种常见的细胞因子受体，它控制着一组细胞因子的活性，即白细胞介素（IL）-6、肿瘤坏死因子 M（OSM）、IL-11、睫状神经营养因子（CNTF）、白血病抑制因子（LIF）、心营养素-1（CT-1）、心营养素样细胞因子（CLC）、IL-27 和神经细胞素（NP）。gp130 和相关细胞因子具有丰富多样的功能。本文第一部分重点介绍 gp130 配体的病理生理学功能。我们特别描述了这些分子的血管作用，并讨论了各自的潜在分子和细胞机制。
