去甲肾上腺素抑制大鼠交感神经元中钙依赖性电位。

Norepinephrine inhibits calcium-dependent potentials in rat sympathetic neurons.

作者信息

Horn J P, McAfee D A

出版信息

Science. 1979 Jun 15;204(4398):1233-5. doi: 10.1126/science.221979.

DOI:10.1126/science.221979

PMID:221979

Abstract

Norepinephrine reversibly antagonizes three calcium-dependent potentials recorded from rat postganglionic neurons. Norepinephrine inhibits the development of a shoulder on the aciton potential, the magnitude of the hyperpolarizing afterpotential, and the rate of rise and amplitude of the calcium spike. The action of norepinephrine is antagonized by the alpha-adrenergic antagonist phentolamine, but not by MJ 1999, a beta-adrenergic antagonist. These results suggest that activation of an alpha-adrenergic receptor may antagonize a voltage-sensitive calcium current.

摘要

去甲肾上腺素可逆性地拮抗从大鼠节后神经元记录到的三种钙依赖性电位。去甲肾上腺素抑制动作电位上肩部的形成、超极化后电位的幅度以及钙棘波的上升速率和幅度。去甲肾上腺素的作用可被α-肾上腺素能拮抗剂酚妥拉明拮抗，但不能被β-肾上腺素能拮抗剂MJ 1999拮抗。这些结果表明，α-肾上腺素能受体的激活可能拮抗电压敏感性钙电流。