MPH, The Neurological Institute of New York, 710 West 168th Street, 6th Floor, New York, NY 10032, USA.
Stroke. 2012 Apr;43(4):1156-8. doi: 10.1161/STROKEAHA.111.643387. Epub 2011 Dec 22.
The purpose of this study was to determine if postmortem intracranial arteries from donors with HIV without stroke have thinner media layers compared with patients without HIV and without stroke.
Cross-sectional cuts from intracranial arteries were stained with van Gieson and hematoxylin and eosin. Arteries were examined for thickness of each arterial layer. Univariable and multivariable models were used for statistical analyses with probability values <0.05 considered significant.
A total of 18 brains were analyzed, 5 with HIV and 13 without. Fifty-five arteries were collected, 15 from HIV brains and 40 from unaffected controls. In univariable analysis, in arteries from HIV-infected brains, the media to wall thickness ratio was smaller than in donors without HIV (0.496 versus 0.563, P=0.017). In multivariable analysis, HIV infection was the only independent predictor of smaller media ratios compared with the same-aged control subjects (P=0.049) but not with aged control subjects (P=0.081).
In patients with HIV without clinical stroke, the media arterial layer is thinner than in patients without HIV. This suggests that a thinner media layer might be a preclinical stage in the development of HIV-related vasculopathy.
本研究旨在确定尸检时无卒中的 HIV 阳性供体颅内动脉的中膜层是否比无 HIV 且无卒中的患者更薄。
对颅内动脉进行横断面切开，用范吉森（Van Gieson）和苏木精-伊红（Hematoxylin and eosin）染色。检查动脉各层的厚度。采用单变量和多变量模型进行统计分析，概率值 <0.05 认为具有统计学意义。
共分析了 18 例大脑，其中 5 例为 HIV 阳性，13 例为 HIV 阴性。共收集了 55 根动脉，其中 15 根来自 HIV 阳性大脑，40 根来自未受影响的对照者。在单变量分析中，HIV 感染大脑中的动脉中膜与管壁厚度比小于无 HIV 感染者（0.496 比 0.563，P=0.017）。在多变量分析中，与同龄对照者相比，HIV 感染是中膜比值较小的唯一独立预测因素（P=0.049），但与老年对照者相比并非如此（P=0.081）。
在无临床卒中的 HIV 阳性患者中，动脉中层较无 HIV 患者薄。这表明，较薄的中膜层可能是 HIV 相关血管病发展的临床前阶段。
