[通过光化学疗法延长移植存活时间。实验和临床结果]

[Prolongation of transplantation survival time by a PUVA treatment. Experimental and clinical results].

作者信息

Gruner S, Oesterwitz H, Kaden J, Meffert H

机构信息

Instiut für Medizinische Immunologie, Bereichs Medizin (Charité), Humboldt-Universität, Berlin, DDR.

出版信息

Z Exp Chir Transplant Kunstliche Organe. 1990;23(1):32-4.

Abstract

The treatment of transplants by a combination of 8-methoxypsoralen and longwave ultraviolet radiation (PUVA) leads to prolongation of the transplants in allogeneic receivers without immunosuppression. The rejection of skin grafts in the mice could be delayed significantly. The rejection of kidney and heart allografts could be prevented completely. A significant diminution of the acute rejection crises and a raising of the one-year survival rate showed a first clinical study by means of PUVA treatment in human kidney grafts.

摘要

采用8-甲氧基补骨脂素与长波紫外线辐射（PUVA）联合治疗移植器官，可使同种异体受体的移植器官在无免疫抑制的情况下延长存活时间。小鼠皮肤移植的排斥反应可显著延迟。肾脏和心脏同种异体移植的排斥反应可完全预防。一项关于PUVA治疗人类肾移植的初步临床研究表明，急性排斥反应危机显著减少，一年生存率提高。

相似文献

1

[Prolongation of transplantation survival time by a PUVA treatment. Experimental and clinical results].[通过光化学疗法延长移植存活时间。实验和临床结果]

Z Exp Chir Transplant Kunstliche Organe. 1990;23(1):32-4.

2

[PUVA treatment of organ transplants--experimental and clinical results].[光化学疗法治疗器官移植——实验与临床结果]

Z Urol Nephrol. 1989 Jan;82(1):1-12.

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Influence of a transfusion of donor leukocytes treated with 8-methoxypsoralen and long-wave ultraviolet light (PUVA) on skin allograft survival in mice.

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Inhibition of rat heart allograft rejection by a PUVA treatment of the graft recipient. Role of cisurocanic acid.通过对移植物受体进行补骨脂素加紫外线A（PUVA）治疗抑制大鼠心脏同种异体移植排斥反应。顺式尿刊酸的作用。

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[Extending the survival time of allogenic heart and kidney transplants in the rat by a combination of PUVA transplant conditioning and cyclosporin treatment of the recipient].[通过补骨脂素紫外线 A 光化学疗法（PUVA）移植预处理和环孢素治疗受体相结合来延长大鼠同种异体心脏和肾脏移植的存活时间]

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Prolongation of skin graft survival in mice by in vitro PUVA treatment and failure of induction of specific immunological memory by PUVA-treated grafts.通过体外补骨脂素加长波紫外线（PUVA）治疗延长小鼠皮肤移植存活时间以及经PUVA处理的移植物诱导特异性免疫记忆失败

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Prolonged rat heart allograft survival and reduced graft immunogenicity after photochemical donor and transplant pretreatment.光化学供体及移植预处理后大鼠心脏同种异体移植物存活时间延长及移植物免疫原性降低。

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