Yoon Kyoung Won, Heo Jin Seok, Choi Dong Wook, Choi Seoung Ho
Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
J Korean Surg Soc. 2011 Dec;81(6):394-401. doi: 10.4174/jkss.2011.81.6.394. Epub 2011 Nov 25.
Some patients who undergo surgical resection of pancreatic cancer survive longer than other patients. The purpose of this study was to identify the factors that affect long-term survival after resection of histopathologically confirmed pancreatic ductal adenocarcinoma.
A single-center, retrospective study was conducted among 164 patients who underwent surgical resection of pancreatic cancer, between May 1995 and December 2004. The patient follow-up process was conducted via telephone survey and review of electronic medical records for at least 5 years or until death.
We compared patients with long-term (≥60 months, n = 19) and short-term survival (<60 months, n = 145). Resection margin status, differentiation of the tumor, tumor stage, pre-operative serum level of albumin, total bilirubin and carbohydrate antigen (CA) 19-9 level are related with survival difference (all factors, P < 0.05). Multivariate analysis revealed that a pre-operative serum total bilirubin level <7 mg/dL and a pre-operative serum CA19-9 level <37 U/mL is a statistically significant prognostic factor for long-term survival.
The preoperative serum total bilirubin and serum CA19-9 levels are associated with long-term survival after surgical resection of pancreatic cancer.
一些接受胰腺癌手术切除的患者比其他患者存活时间更长。本研究的目的是确定影响经组织病理学确诊的胰腺导管腺癌切除术后长期生存的因素。
对1995年5月至2004年12月期间164例行胰腺癌手术切除的患者进行单中心回顾性研究。通过电话调查和查阅电子病历对患者进行至少5年的随访或直至死亡。
我们比较了长期生存（≥60个月，n = 19）和短期生存（<60个月，n = 145）的患者。切缘状态、肿瘤分化程度、肿瘤分期、术前血清白蛋白水平、总胆红素水平和糖类抗原（CA）19-9水平与生存差异相关（所有因素，P < 0.05）。多因素分析显示，术前血清总胆红素水平<7 mg/dL和术前血清CA19-9水平<37 U/mL是长期生存的统计学显著预后因素。
术前血清总胆红素和血清CA19-9水平与胰腺癌手术切除后的长期生存相关。
