Elfeldt R, Leuze D, Thiede A, Seifert J
Abteilung Allgemeine Chirurgie, Universität Kiel.
Z Exp Chir Transplant Kunstliche Organe. 1990;23(1):47-50.
Sutures of the colon can be insufficient or leaking. This leads in some cases to a peritonitis or sepsis sometimes with lethal outcome. Therefore experiments in animals were performed to investigate the effect of additional applied biogenic glue. Especially in the beginning of the wound healing, at the 4th postoperative day, the firmness could be improved by fibrin glue. The bursting pressure of fibrin glue sealed colon sutures was 94 mmHg, whereas only 66 mmHg was observed in the control group. This additional firmness remains over the whole observation time of 3 weeks. An intensified proliferation of the connective tissue is responsible for this observation which could be substantiated by histological investigations and by measuring the thickness of the scar. If biogenic glue is used in animals it can have the consequence that the recipient reacts with the production of antibodies, since the components of the glue are proteins from different species. Investigations of the serum of animals which had been treated with fibrin glue revealed in a part of them precipitating antibodies against fibrinogen. With regard to this observation a second application of biogenic glue must be done with the necessary precaution.
结肠缝合可能不充分或发生渗漏。在某些情况下，这会导致腹膜炎或败血症，有时甚至会导致致命后果。因此，进行了动物实验以研究额外应用生物胶水的效果。特别是在伤口愈合初期，术后第4天，纤维蛋白胶可提高结肠缝合处的牢固性。纤维蛋白胶密封的结肠缝合处的破裂压力为94 mmHg，而对照组仅为66 mmHg。这种额外的牢固性在整个3周的观察期内都保持存在。结缔组织的增殖加剧是造成这一观察结果的原因，这可以通过组织学研究和测量疤痕厚度得到证实。如果在动物身上使用生物胶水，可能会导致受体产生抗体反应，因为胶水的成分是来自不同物种的蛋白质。对接受纤维蛋白胶治疗的动物血清进行的调查显示，其中一部分动物产生了针对纤维蛋白原的沉淀抗体。鉴于这一观察结果，再次应用生物胶水时必须采取必要的预防措施。
