局部使用庆大霉素与纤维蛋白胶联合使用时并不能提供额外的吻合强度。
Topical gentamicin does not provide any additional anastomotic strength when combined with fibrin glue.
机构信息
Department of Surgery, Providence Hospital and Medical Centers, Southfield, MI 48075, USA.
出版信息
Am J Surg. 2011 Mar;201(3):339-43. doi: 10.1016/j.amjsurg.2010.09.022.
BACKGROUND
We evaluated the effect of a combination of fibrin sealant and topical gentamicin on a colonic anastomosis in a rat model.
METHODS
Partial anastomosis in the transverse colon was performed in 70 male Sprague-Dawley rats aged 6 to 10 weeks using 5 interrupted sutures. The rats were divided into 4 groups (control, gentamicin, fibrin glue, and combination). On postoperative days 3 and 5, the rats in each group were killed, anastomotic bursting pressures scores and bowel loop adhesions were determined, and histologic examination was performed.
RESULTS
No significant difference was noted in the bursting pressures, adhesions, inflammatory infiltrates, fibroblasts, or neoangiogenesis between the fibrin-glue only and the combination groups for both the day 3 and day 5 subgroups.
CONCLUSIONS
The combination of topical gentamicin and fibrin glue had little effect because the combination did not provide additional anastomotic strength or decrease the number of adhesions when compared with fibrin glue alone.
背景
我们评估了纤维蛋白密封剂和局部庆大霉素联合应用于大鼠模型中结肠吻合术的效果。
方法
6 至 10 周龄雄性 Sprague-Dawley 大鼠 70 只进行横结肠部分吻合术，使用 5 个间断缝线。将大鼠分为 4 组（对照组、庆大霉素组、纤维蛋白胶组和联合组）。在术后第 3 天和第 5 天，每组大鼠处死，测定吻合口爆裂压评分和肠袢粘连程度，并进行组织学检查。
结果
纤维蛋白胶组和联合组在第 3 天和第 5 天亚组的爆裂压、粘连、炎症浸润、成纤维细胞或新生血管形成方面均无显著差异。
结论
与单独使用纤维蛋白胶相比，局部应用庆大霉素和纤维蛋白胶联合应用的效果不大，因为联合应用并没有提供额外的吻合强度或减少粘连的数量。
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