Division of Nephrology, Endocrinology, and Metabolism, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
J Ren Nutr. 2012 Jan;22(1):98-101. doi: 10.1053/j.jrn.2011.10.031.
The kidney plays an important role in the regulation of mineral metabolism. As kidney function declines, there is a progressive deterioration in mineral homeostasis, along with various abnormalities, including bone disease and vascular calcification, which has recently been named as "Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD)." Although the precise mechanisms of this systemic disorder remain to be elucidated, accumulating evidence suggest that uremic toxins contribute substantially to the development of CKD-MBD, partly through evoking oxidative stress in the bone and cardiovascular systems. This brief review summarizes recent work on the role of uremic toxins and oxidative stress in the development of CKD-MBD.
肾脏在矿物质代谢调节中起着重要作用。随着肾功能下降，矿物质内环境稳态逐渐恶化，同时出现各种异常，包括骨骼疾病和血管钙化，最近被命名为“慢性肾脏病-矿物质和骨代谢异常（CKD-MBD）”。尽管这种全身性疾病的确切机制仍有待阐明，但越来越多的证据表明，尿毒症毒素在 CKD-MBD 的发展中起重要作用，部分是通过在骨骼和心血管系统中引发氧化应激。这篇简要综述总结了尿毒症毒素和氧化应激在 CKD-MBD 发展中的作用的最新研究进展。
