[CD40阻断对大鼠急性肾移植排斥反应的影响]
[Effect of CD40 blockade on acute renal graft rejection in rats].
作者信息
Shi Xiang-hua, Liu Xiao-you, Sun Xu-yong, Zhao Ming
机构信息
Department of Organ Transplantation, Southern Medical University, Guangzhou, China.
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2011 Dec;31(12):2085-6.
OBJECTIVE
To explore the effect of CD40 blockade in suppressing acute rejection of renal graft in rats.
METHODS
With Wistar rats as the donor and male SD rats as the recipients, rat models of acute renal graft rejection was established. The rat models were divided into therapy group and control group, and in the former group, CD40 ligand (CD40L) monoclonal antibody was injected daily for 4 consecutive days starting on the next day following kidney transplantation. On day 5 after the transplantation, the renal graft was harvested for histological examination, and graft rejection was evaluated semiquantitatively.
RESULTS
The mean semiquantitative score of the renal graft was 0.63∓0.52 in the therapy group, significantly lower than that of the control group (3.72∓1.48, P<0.05).
CONCLUSION
CD40L monoclonal antibody can inhibit acute renal graft in rats.
目的
探讨CD40阻断在抑制大鼠肾移植急性排斥反应中的作用。
方法
以Wistar大鼠为供体，雄性SD大鼠为受体，建立大鼠急性肾移植排斥反应模型。将大鼠模型分为治疗组和对照组，治疗组于肾移植术后次日起连续4天每日注射CD40配体（CD40L）单克隆抗体。移植后第5天，摘取肾移植物进行组织学检查，并对移植排斥反应进行半定量评估。
结果
治疗组肾移植物半定量评分均值为0.63±0.52，显著低于对照组（3.72±1.48，P<0.05）。
结论
CD40L单克隆抗体可抑制大鼠急性肾移植排斥反应。
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