Dnmt3a 沉默造血干细胞自我更新。
Dnmt3a silences hematopoietic stem cell self-renewal.
机构信息
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Children's Hospital Boston, Boston, Massachusetts, USA.
出版信息
Nat Genet. 2011 Dec 27;44(1):13-4. doi: 10.1038/ng.1043.
DOI:10.1038/ng.1043
PMID:22200773
Abstract
DNA methylation is an epigenetic mark stably directing gene expression throughout development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in silencing self-renewal genes in hematopoietic stem cells (HSCs) to permit efficient hematopoietic differentiation.
摘要
DNA 甲基化是一种表观遗传标记，可在整个发育过程中稳定地指导基因表达。一项新的研究揭示了 DNA 甲基转移酶 Dnmt3a 在沉默造血干细胞 (HSCs) 中的自我更新基因以实现高效造血分化中的作用。
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