4-磷酸-D-赤藓糖酸盐的一种简易合成路线。
A Simple Route for Synthesis of 4-Phospho-D-Erythronate.
作者信息
Novikov Yehor, Copley Shelley D, Eaton Bruce E
机构信息
Department of Molecular, Cellular and Developmental Biology and Cooperative Institute for Research in Environmental Sciences, University of Colorado at Boulder, Boulder, CO 80309.
出版信息
Tetrahedron Lett. 2011 Apr 20;52(16):1913-1915. doi: 10.1016/j.tetlet.2011.02.045.
Abstract
4-Phospho-D-erythronate is an intermediate in synthesis of pyridoxal 5'-phosphate in some bacteria and an inhibitor of ribose 5-phosphate isomerase. Previous synthetic schemes for the preparation of 4-phospho-D-erythronate required expensive precursors and typically gave low yields. We report a straightforward synthesis of 4-phospho-D-erythronate from the inexpensive precursor D-erythronolactone in 5 steps with a preparatively useful yield of 22%.
摘要
4-磷酸-D-赤藓糖酸盐是某些细菌中5'-磷酸吡哆醛合成的中间体，也是5-磷酸核糖异构酶的抑制剂。以往制备4-磷酸-D-赤藓糖酸盐的合成方案需要昂贵的前体，且产率通常较低。我们报道了一种从廉价前体D-赤藓糖内酯出发，经5步反应直接合成4-磷酸-D-赤藓糖酸盐的方法，其制备产率为22%，具有实用价值。
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