Lazrishvili I, Bikashvili T, Shukakidze A, Samchkuashvili K, Shavlakadze O
Beritashvili Institute of Physiology, Tbilisi, Georgia.
Georgian Med News. 2011 Nov;11(200):102-6.
Manganese is an essential trace element for all living organisms. Though some neurological dysfunction take place during intoxication caused by excessive exposure of this metal. The goal of this research was to elucidate the emotional state, in particular anxiety and fear in three groups of young male rats. Two groups of 30 day old rat pups were given drinking water with MnCl(2)·4H(2)O dissolved in, the doses were 1mg/ml (I group) and 10 mg/ml (II group), and the third group was control animals. Before starting and a day after of termination manganese consumption the animals were tested in the "open field" and "elevated-plus maze". In two month old rat pups compared to one month ones the elevation of anxiety was observed that led to increase of fear. 30 day intoxication of one month old rat pups with both doses of manganese (1 and 10 mg/ml) induces: strengthening of motor and orienting-explorative activity, decrease in the level of anxiety and fear. During the intoxication of animals with above mentioned doses of manganese chloride the dose-dependant effect is not observed.
锰是所有生物必需的微量元素。尽管在因过度接触这种金属而导致中毒期间会出现一些神经功能障碍。本研究的目的是阐明三组年轻雄性大鼠的情绪状态，特别是焦虑和恐惧。两组30日龄的幼鼠饮用溶解有MnCl₂·4H₂O的水，剂量分别为1mg/ml（I组）和10mg/ml（II组），第三组为对照动物。在开始摄入锰和停止摄入锰一天后，对动物进行“旷场试验”和“高架十字迷宫试验”。与1月龄幼鼠相比，2月龄幼鼠的焦虑程度升高，导致恐惧增加。1月龄幼鼠用两种剂量的锰（1和10mg/ml）进行30天中毒处理后，会出现：运动和定向探索活动增强，焦虑和恐惧水平降低。在用上述剂量的氯化锰使动物中毒期间，未观察到剂量依赖性效应。
