Okabe Koji, Okamoto Fujio, Kajiya Hiroshi
Department of Physiological Science and Molecular Biology, Fukuoka Dental College, Japan.
Clin Calcium. 2012 Jan;22(1):19-26.
Although it is believed that odontoclasts, which mediated root resorption of deciduous teeth, possess common properties to osteoclasts, these regulatory mechanisms differ from osteoclastic bone resorption. It is well established that calcitonin receptor is an important osteoclast marker and that calcitonin is a potent inhibitory hormone of osteoclastic bone resorption. However, the presence and function of calcitonin receptors in human odontoclasts are still controversial. We summarize the physiological properties and differentiation mechanisms of odontoclasts, and the effects of calcitonin on root resorption, including our recent results using human odontoclasts and periodontal ligament cells freshly isolated from deciduous tooth roots.
虽然人们认为介导乳牙牙根吸收的破牙细胞具有与破骨细胞相同的特性，但这些调节机制与破骨细胞性骨吸收不同。众所周知，降钙素受体是一种重要的破骨细胞标志物，而降钙素是破骨细胞性骨吸收的一种有效抑制激素。然而，人破牙细胞中降钙素受体的存在和功能仍存在争议。我们总结了破牙细胞的生理特性和分化机制，以及降钙素对牙根吸收的影响，包括我们最近使用从乳牙牙根新鲜分离的人破牙细胞和牙周膜细胞所获得的结果。
