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甲状旁腺激素(PTH)在口腔疾病治疗中的潜在应用

[Potential use of parathyroid hormone (PTH) in the treatments for oral diseases].

作者信息

Tanaka Soichi, Hata Kenji, Yoneda Toshiyuki

机构信息

Department of Biochemistry, Osaka University Graduate School of Dentistry, Japan.

出版信息

Clin Calcium. 2012 Jan;22(1):75-82.

Abstract

Bone formation is the key for successful dental treatments including periodontal tissue regeneration osseointegration of implant placement in which new alveolar bone formation is mandatory. Parathyroid hormone (PTH) is a peptide hormone containing 84 amino acids. Accumulated results show that intermittent PTH administration increases bone mass. Accordingly, recombinant N-terminal fragment of human PTH (1-34) , Teriparatide, is used for the treatments of osteoporosis worldwide. It is, therefore, expected that PTH has the potential to be a new therapeutic intervention for oral diseases that require increased bone remodeling and new bone formation.

摘要

骨形成是包括牙周组织再生、种植体植入骨结合等成功牙科治疗的关键,其中新的牙槽骨形成是必不可少的。甲状旁腺激素(PTH)是一种含84个氨基酸的肽类激素。累积的研究结果表明,间歇性给予PTH可增加骨量。因此,重组人PTH(1-34)片段特立帕肽在全球范围内被用于治疗骨质疏松症。因此,人们期望PTH有可能成为一种针对需要增加骨重塑和新骨形成的口腔疾病的新型治疗手段。

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