Sano Rui, Teranishi Masaaki, Yamazaki Masahiro, Isoda Haruo, Naganawa Shinji, Sone Michihiko, Hiramatsu Mariko, Yoshida Tadao, Suzuki Hirokazu, Nakashima Tsutomu
Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Japan.
Acta Otolaryngol. 2012 Mar;132(3):241-6. doi: 10.3109/00016489.2011.639085. Epub 2011 Dec 27.
Contrast enhancement of the inner ear by three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging (3D-FLAIR MRI) taken 4 h after intravenous gadolinium (Gd) injection was better than when taken at 10 min. Using heavily T2-weighted 3D-FLAIR MRI, visualization of endolymphatic hydrops (EH) was possible in the vestibule and the cochlea after a standard intravenous dose of Gd.
To define a suitable time point for imaging Gd uptake in the inner ear acquired with heavily T2-weighted 3D-FLAIR MRI after standard intravenous Gd administration.
Using a 3 Tesla MRI unit, heavily T2-weighted 3D-FLAIR MRI images were taken twice at approximately 10 min (conventional timing) and 4 h after intravenous gadodiamide (0.1 mmol/kg) injection in 10 patients with inner ear diseases including Ménière's disease.
The 4 h delay increased Gd enhancement of the 3D-FLAIR MRI images of the perilymphatic space in both symptomatic and asymptomatic ears. The increase in Gd enhancement was greater in symptomatic than in asymptomatic ears. Using this heavily T2-weighted 3D-FLAIR technique, EH was observed in both the cochlea and vestibule in images taken 4 h after the intravenous Gd injection.
静脉注射钆（Gd）后4小时进行三维液体衰减反转恢复磁共振成像（3D-FLAIR MRI）对内耳的对比增强效果优于10分钟时。在标准静脉注射Gd后，使用重T2加权3D-FLAIR MRI能够在前庭和耳蜗中观察到内淋巴积水（EH）。
确定标准静脉注射Gd后，使用重T2加权3D-FLAIR MRI获取内耳Gd摄取成像的合适时间点。
使用3特斯拉MRI设备，对10例患有内耳疾病（包括梅尼埃病）的患者在静脉注射钆双胺（0.1 mmol/kg）后约10分钟（传统时间点）和4小时两次进行重T2加权3D-FLAIR MRI成像。
4小时的延迟增加了有症状和无症状耳的外淋巴间隙3D-FLAIR MRI图像的Gd增强。有症状耳的Gd增强增加幅度大于无症状耳。使用这种重T2加权3D-FLAIR技术，在静脉注射Gd后4小时拍摄的图像中，在耳蜗和前庭均观察到了EH。
