ERCC1 多态性与中国人群成人脑胶质瘤风险：一项基于医院的病例对照研究。
ERCC1 polymorphisms and risk of adult glioma in a Chinese population: a hospital-based case-control study.
机构信息
Department of Neurosurgery, The Second Affiliated Hospital of Wenzhou Medical College, Zhejiang Province, China.
出版信息
Cancer Invest. 2012 Mar;30(3):199-202. doi: 10.3109/07357907.2011.651233. Epub 2011 Dec 27.
To examine the associations of two polymorphisms in excision repair cross-complementing rodent repair deficiency complementation group 1 (ERCC1) gene, C8092A (rs3212986) and T19007C (rs11615), with the risk of adult glioma, we performed a hospital-based case-control study with 257 new cases of glioma and 278 controls in Wenzhou, China. Results showed that polymorphisms C8092A and T19007C in ERCC1 gene were not associated with the risk of glioma in a Chinese population. Further studies in Chinese populations with larger sample sizes are still warranted.
为了研究切除修复交叉互补基因 1（ERCC1）基因中两个多态性（C8092A[rs3212986]和 T19007C[rs11615]）与成人脑胶质瘤风险的关联，我们在中国温州进行了一项基于医院的病例对照研究，共纳入 257 例新诊断的脑胶质瘤患者和 278 例对照。结果显示，ERCC1 基因中的多态性 C8092A 和 T19007C 与中国人群脑胶质瘤的发病风险无关。仍需要在更大的中国人群样本中进行进一步的研究。
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