Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland.
Front Biosci (Landmark Ed). 2012 Jan 1;17(1):40-53. doi: 10.2741/3914.
Histamine influences many cell types involved in the regulation of innate and adaptive immune responses including antigen-presenting cells (APCs), Natural Killer (NK) cells, epithelial cells, T lymphocytes and B lymphocytes. These cells express histamine receptors (HRs) and also secrete histamine, which can selectively recruit the major effector cells into tissue sites and affect their maturation, activation, polarization and effector functions leading to tolerogenic or pro-inflammatory responses. Histamine and its four receptors represent a complex system of immunoregulation with distinct effects of receptor subtypes and their differential expression, which changes according to the stage of cell differentiation as well as micro-environmental influences. In this review, we discuss histamine receptor expression and differential activation of cells within both the innate and adaptive immune response and the signal transduction mechanisms which influence their activity.
组胺影响许多参与固有和适应性免疫反应调节的细胞类型，包括抗原呈递细胞 (APC)、自然杀伤 (NK) 细胞、上皮细胞、T 淋巴细胞和 B 淋巴细胞。这些细胞表达组胺受体 (HR)，也分泌组胺，它可以选择性地将主要效应细胞募集到组织部位，并影响它们的成熟、激活、极化和效应功能，导致耐受或促炎反应。组胺及其四个受体代表了一个复杂的免疫调节系统，其受体亚型具有不同的作用，它们的表达也不同，这取决于细胞分化的阶段以及微环境的影响。在这篇综述中，我们讨论了固有和适应性免疫反应中细胞内组胺受体的表达和差异激活，以及影响其活性的信号转导机制。
