Institute of Biophysics, University of Linz, A-4040 Linz, Austria.
Front Biosci (Landmark Ed). 2012 Jan 1;17(4):1304-22. doi: 10.2741/3988.
Ca2+ release-activated Ca2+ channels mediate a sustained Ca2+ influx following depletion of endoplasmic reticulum stores. This signalling cascade that triggers T-cell activation or mast cell degranulation involves STIM1, the Ca2+ sensor in the endoplasmic reticulum, and the Ca2+ selective Orai channel in the plasma membrane. This review describes the molecular mechanism (s) governing the STIM1/Orai signalling machinery. Moreover, we provide an overview on additional proteins modulating or interacting with the STIM1/Orai1 system. A structure-function relationship highlights regions within STIM1/Orai proteins contributing to activation, permeation and inactivation of CRAC currents.
钙离子释放激活的钙离子通道介导内质网储存耗尽后的持续钙离子内流。这种信号级联反应触发 T 细胞激活或肥大细胞脱颗粒，涉及内质网中的钙离子传感器 STIM1 和质膜中的钙离子选择性 Orai 通道。本综述描述了调控 STIM1/Orai 信号机制的分子机制。此外，我们还概述了调节或与 STIM1/Orai1 系统相互作用的其他蛋白质。结构-功能关系突出了 STIM1/Orai 蛋白中的区域，这些区域有助于 CRAC 电流的激活、通透和失活。
