London Regional Cancer Center, University of Western Ontario, London, ON, Canada N6A 4L6.
Front Biosci (Landmark Ed). 2012 Jan 1;17(5):1775-94. doi: 10.2741/4018.
CD44 and RHAMM are two extracellar matrix receptors whose principle ligand is the polysaccharide hyaluronan (HA). Both proteins are involved in wound repair and their aberrant regulation contributes to a variety of diseases including arthritis and cancer. Over the past decade, a number of peptide-based therapeutics that block the binding of CD44 or RHAMM-specific ligands have been developed and tested in experimental models of disease. Here, we review the structure of each of these proteins, the functions they control and the mechanisms, including their interactions with each other, responsible for these functions. We also review the development of peptide mimics that block the key functions of CD44 and RHAMM and their use in experimental models of disease.
CD44 和 RHAMM 是两种细胞外基质受体，其主要配体是多糖透明质酸 (HA)。这两种蛋白都参与伤口修复，其异常调节与包括关节炎和癌症在内的多种疾病有关。在过去的十年中，已经开发出许多基于肽的治疗药物，这些药物可以阻断 CD44 或 RHAMM 特异性配体的结合，并在疾病的实验模型中进行了测试。在这里，我们回顾了这些蛋白的结构、它们控制的功能以及这些功能的机制，包括它们之间的相互作用。我们还回顾了阻断 CD44 和 RHAMM 的关键功能的肽模拟物的开发及其在疾病的实验模型中的应用。
