造血癌症微环境的结构与功能：聚焦慢性淋巴细胞白血病
Structure and function of the hematopoietic cancer niche: focus on chronic lymphocytic leukemia.
作者信息
Fecteau Jessi-F, Kipps Thomas J
机构信息
Rebecca and John Moores Cancer Center, UCSD, La Jolla, CA 92093-0820, USA.
出版信息
Front Biosci (Schol Ed). 2012 Jan 1;4(1):61-73. doi: 10.2741/s251.
Abstract
Chronic Lymphocytic Leukemia (CLL) is a B cell malignancy characterized by the accumulation of mature monoclonal CD5-positive B cells in the blood, secondary lymphoid tissues, and marrow. The infiltration of CLL cells in lymphoid tissues is a key element of disease pathogenesis. It is in such tissues that are found the microenvironments that provide CLL cells protection from spontaneous and/or drug-induced apoptosis. CLL cells actively shape their microenvironment by producing cytokines and chemokines, and by subverting normal accessory cells to promote leukemia-cell survival, proliferation, and escape from immune detection. In this review, we discuss how CLL cells disrupt the niches required for normal hematopoiesis or immune function and subvert normal cells in the microenvironment to support neoplastic cell growth and survival.
摘要
慢性淋巴细胞白血病（CLL）是一种B细胞恶性肿瘤，其特征是成熟的单克隆CD5阳性B细胞在血液、二级淋巴组织和骨髓中积聚。CLL细胞浸润淋巴组织是疾病发病机制的关键因素。正是在这些组织中发现了为CLL细胞提供保护使其免受自发和/或药物诱导凋亡的微环境。CLL细胞通过产生细胞因子和趋化因子，以及颠覆正常辅助细胞来促进白血病细胞的存活、增殖和逃避免疫检测，从而积极塑造其微环境。在本综述中，我们讨论了CLL细胞如何破坏正常造血或免疫功能所需的生态位，并颠覆微环境中的正常细胞以支持肿瘤细胞的生长和存活。
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