Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Department of Medical Biochemistry, Medical Research Division, National Research Centre, Cairo 12622, Egypt.
Int J Mol Sci. 2020 May 11;21(9):3387. doi: 10.3390/ijms21093387.
An increased focus is being placed on the tumorigenesis and contexture of tumor microenvironment in hematopoietic and solid tumors. Despite recent clinical revolutions in adoptive T-cell transfer approaches and immune checkpoint blockade, tumor microenvironment is a major obstacle to tumor regression in B-cell malignancies. A transcriptional alteration of coding and non-coding RNAs, such as microRNAs (miRNAs), has been widely demonstrated in the tumor microenvironment of B-cell malignancies. MiRNAs have been associated with different clinical-biological forms of B-cell malignancies and involved in the regulation of B lymphocyte development, maturation, and function, including B-cell activation and malignant transformation. Additionally, tumor-secreted extracellular vesicles regulate recipient cell functions in the tumor microenvironment to facilitate metastasis and progression by delivering miRNA contents to neighboring cells. Herein, we focus on the interplay between miRNAs and tumor microenvironment components in the different B-cell malignancies and its impact on diagnosis, proliferation, and involvement in treatment resistance.
人们越来越关注造血系统肿瘤和实体瘤的肿瘤发生和肿瘤微环境结构。尽管最近在过继性 T 细胞转移方法和免疫检查点阻断方面取得了临床突破，但肿瘤微环境仍是 B 细胞恶性肿瘤肿瘤消退的主要障碍。编码和非编码 RNA（如 microRNAs，miRNAs）的转录改变已在 B 细胞恶性肿瘤的肿瘤微环境中得到广泛证实。miRNAs 与 B 细胞恶性肿瘤的不同临床生物学形式相关，并参与 B 淋巴细胞发育、成熟和功能的调节，包括 B 细胞激活和恶性转化。此外，肿瘤分泌的细胞外囊泡通过将 miRNA 内容物递送至邻近细胞来调节肿瘤微环境中受体细胞的功能，从而促进转移和进展。在此，我们重点关注 miRNA 与不同 B 细胞恶性肿瘤肿瘤微环境成分之间的相互作用及其对诊断、增殖和参与治疗耐药性的影响。
