Fukuda Koji, Kobayashi Aya, Watabe Kounosuke
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University, School of Medicine, Springfield, IL 627794-9626, USA.
Front Biosci (Schol Ed). 2012 Jan 1;4(2):787-98. doi: 10.2741/s299.
The tumor progression is not only regulated by metastasis promoting and suppressing genes in cancer cells but it is also strongly influenced by the interaction between cancer cells and the stromal cells. An abundance of inflammatory mediators and leukocytes has been known to promote cancer metastasis, and tumor associated macrophages (TAM) are the key players in the link between inflammation and cancer. TAM are derived from peripheral blood monocytes that are recruited into the tumor by inflammatory chemokines. Upon activation by cancer cells, TAM gain the ability of pro-tumoral functions including expression of various growth factors, promotion of angiogenesis and suppression of adaptive immunity, and many of these factors also play critical roles in cancer metastasis. In this review, we will summarize the recent information about the function of TAM in the inflammatory micro-environment of solid tumors and discuss the potential targets for future therapeutic approaches.
肿瘤进展不仅受癌细胞中促进转移和抑制转移基因的调控，还受到癌细胞与基质细胞之间相互作用的强烈影响。已知大量炎症介质和白细胞可促进癌症转移，而肿瘤相关巨噬细胞（TAM）是炎症与癌症之间联系的关键参与者。TAM来源于外周血单核细胞，这些单核细胞被炎症趋化因子募集到肿瘤中。在被癌细胞激活后，TAM获得促肿瘤功能的能力，包括表达各种生长因子、促进血管生成和抑制适应性免疫，其中许多因子在癌症转移中也起着关键作用。在本综述中，我们将总结关于TAM在实体瘤炎症微环境中功能的最新信息，并讨论未来治疗方法的潜在靶点。
