Veterans Affairs Boston Healthcare System and Harold Goodglass Boston University Aphasia Research Center, Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
Arch Phys Med Rehabil. 2012 Jan;93(1 Suppl):S26-34. doi: 10.1016/j.apmr.2011.04.026.
Repetitive transcranial magnetic stimulation (rTMS) has been reported to improve naming in chronic stroke patients with nonfluent aphasia since 2005. In part 1, we review the rationale for applying slow, 1-Hz, rTMS to the undamaged right hemisphere in chronic nonfluent aphasia patients after a left hemisphere stroke; and we present a transcranial magnetic stimulation (TMS) protocol used with these patients that is associated with long-term, improved naming post-TMS. In part 2, we present results from a case study with chronic nonfluent aphasia where TMS treatments were followed immediately by speech therapy (constraint-induced language therapy). In part 3, some possible mechanisms associated with improvement after a series of TMS treatments in stroke patients with aphasia are discussed.
自 2005 年以来,重复经颅磁刺激(rTMS)已被报道可改善非流利性失语症慢性卒中患者的命名能力。在第 1 部分中,我们回顾了将缓慢的 1Hz rTMS 应用于左半球卒中后慢性非流利性失语症患者未受损的右半球的基本原理;我们还介绍了一种与 rTMS 后长期、改善命名相关的经颅磁刺激(TMS)方案。在第 2 部分中,我们介绍了一项慢性非流利性失语症病例研究的结果,其中 TMS 治疗后立即进行语言治疗(强制性语言治疗)。在第 3 部分中,讨论了与一系列卒中后失语症患者 rTMS 治疗后改善相关的一些可能机制。