Yatsuoka Toshimasa, Nishimura Yoji, Sakamoto Hirohiko, Tanaka Yoichi, Yamaguchi Kensei
Division of Gastroenterological Surgery, Saitama Cancer Center.
Gan To Kagaku Ryoho. 2011 Nov;38(12):2057-9.
A 56-year-old woman was referred to our hospital because of melena. After examinations she was diagnosed with rectal cancer. Anterior resection was performed and the final diagnosis was Stage IIIa. She was treated with adjuvant chemotherapy consisting of UFT/Uzel for one year, followed by UFT alone for one year. Two years after the surgery, abdominal CT suggested solitary paraaortic lymph node metastasis. As the patient denied a surgical treatment, mFOLFOX6 chemotherapy was induced. However, the patient developed a grade 3 allergic side effect, FOLFIRI was administered. Six months after the chemotherapy was started, the paraaortic lymph node metastasis had disappeared. After 50 courses, the case was considered to have achieved a clinical CR which has been maintained now. FOLFIRI was effective for recurrent rectal cancer with paraaortic LN metastasis.
一名56岁女性因黑便被转诊至我院。经检查，她被诊断为直肠癌。行前切除术，最终诊断为Ⅲa期。她接受了为期一年的以优福定/优泽尔组成的辅助化疗，之后单独使用优福定治疗一年。术后两年，腹部CT提示主动脉旁孤立性淋巴结转移。由于患者拒绝手术治疗，遂采用mFOLFOX6化疗。然而，患者出现了3级过敏副作用，于是给予FOLFIRI化疗。化疗开始6个月后，主动脉旁淋巴结转移消失。经过50个疗程后，该病例被认为达到了临床完全缓解，目前仍处于缓解状态。FOLFIRI对伴有主动脉旁淋巴结转移的复发性直肠癌有效。
