Bresler V M, Nikiforov A A
Tsitologiia. 1979 Apr;21(4):414-8.
Exogenous cyclic 3',5'-AMP (cAMP) and substances known to increase the intracellular concentration of this nucleotide (isoproterenol, theophylline, noradrenaline, lactate) were shown to inhibit the transport of fluorescein (a weak organic acid) into the rat renal proximal tubules at 20 degrees C. Carbacholine decreasing intracellular cAMP concentration stimulated the transport. Propranolol, a beta-adrenergic blockator, diminished significantly the inhibitory effect of noradrenaline on the transport. Lactate and carbacholine when added simultaneously, neutralize their action. The inhibitory action of intracellular cAMP on the transport is supposed to be a result of the diminition of a pool of endogenous weak organic acids which may take part in the exchange of diffusion with the marker anion across basal plasma membrane.
已表明，外源性环3',5'-腺苷酸（cAMP）以及已知可增加该核苷酸细胞内浓度的物质（异丙肾上腺素、茶碱、去甲肾上腺素、乳酸盐）在20℃时可抑制荧光素（一种弱有机酸）向大鼠近端肾小管的转运。降低细胞内cAMP浓度的卡巴胆碱可刺激转运。β-肾上腺素能阻滞剂普萘洛尔可显著减弱去甲肾上腺素对转运的抑制作用。乳酸盐和卡巴胆碱同时添加时，会相互抵消其作用。细胞内cAMP对转运的抑制作用被认为是内源性弱有机酸池减少的结果，这些弱有机酸可能参与与标记阴离子跨基底质膜的扩散交换。
