Ichibangase A, Nishikawa M, Iwasaka T, Kobayashi T, Inada M
Second Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Acta Neurol Scand. 1990 Jun;81(6):491-8. doi: 10.1111/j.1600-0404.1990.tb01006.x.
To assess the effects of thyroid hormone and cardiac function on senile dementia, relations between serum thyroid hormone concentrations, hemodynamic parameters and dementia rating scale scores were studied in 83 subjects aged 70 and over. Age and serum-free T3 concentrations had a significantly negative correlation in all subjects and in subjects without dementia, but not when analysed only in dementia subjects. Regarding the genesis of dementia, serum free T3 concentrations and cardiac index were both significantly lower in cerebrovascular dementia than in those without dementia. Moreover, subjects with cerebrovascular dementia showed significantly lower serum free T3 concentrations and cardiac index than those with senile dementia of Alzheimer's type in all age groups. These findings suggest that cognitive function is closely related to serum free T3 and cardiac function in subjects with cerebrovascular dementia and that serum free T3 concentrations may be a good indicator, reflecting health and cognitive status.
为评估甲状腺激素和心功能对老年痴呆的影响，对83名70岁及以上的受试者进行研究，分析血清甲状腺激素浓度、血流动力学参数与痴呆评定量表评分之间的关系。在所有受试者及非痴呆受试者中，年龄与血清游离T3浓度呈显著负相关，但仅在痴呆受试者中分析时无此相关性。关于痴呆的发病机制，脑血管性痴呆患者的血清游离T3浓度和心脏指数均显著低于非痴呆患者。此外，在所有年龄组中，脑血管性痴呆患者的血清游离T3浓度和心脏指数均显著低于阿尔茨海默型老年痴呆患者。这些结果表明，脑血管性痴呆患者的认知功能与血清游离T3和心功能密切相关，血清游离T3浓度可能是反映健康和认知状态的良好指标。
