Calandre E P, Dominguez-Granados R, Gomez-Rubio M, Molina-Font J A
Clinical Pharmacology Department, University Hospital, Granada, Spain.
Acta Neurol Scand. 1990 Jun;81(6):504-6. doi: 10.1111/j.1600-0404.1990.tb01008.x.
The Wechsler Intelligence Scales for Children was applied to 64 epileptic children and 60 healthy subjects; patients followed chronic treatment with valproic acid (n = 32) or phenobarbital (n = 32). None of the children suffered mental retardation or neurological abnormalities. The test was repeated after a 9-12 month interval: 26 of the valproate treated children and 23 of the phenobarbital-treated children performed the second evaluation. At baseline, total, verbal and performance IQ scores of children receiving phenobarbital were lower than those of controls. When the results of the first and the second tests were compared, a significant increase in IQ scores was detected among controls and patients treated with valproic acid, but not among phenobarbital-treated patients. It is concluded that long-term phenobarbital therapy induces a significant impairment in learning ability whereas long-term valproate therapy does not exert a noticeable noxious effect at this respect.
韦氏儿童智力量表应用于64名癫痫儿童和60名健康受试者；患者接受丙戊酸（n = 32）或苯巴比妥（n = 32）的长期治疗。所有儿童均无智力迟钝或神经学异常。在9至12个月的间隔后重复测试：26名接受丙戊酸盐治疗的儿童和23名接受苯巴比妥治疗的儿童进行了第二次评估。在基线时，接受苯巴比妥治疗的儿童的总智商、言语智商和操作智商得分低于对照组。当比较第一次和第二次测试的结果时，在对照组和接受丙戊酸治疗的患者中检测到智商得分显著增加，但在接受苯巴比妥治疗的患者中未检测到。结论是，长期苯巴比妥治疗会导致学习能力显著受损，而长期丙戊酸盐治疗在这方面不会产生明显的有害影响。
