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亚洲象(印度象)中由鸟分枝杆菌鸟亚种引起的播散性感染。

Disseminated infection due to Mycobacterium avium subsp. avium in an Asian elephant (Elephas maximus).

作者信息

Yong Hwanyul, Choi Go-Eun, Lee Byung Soo, Whang Jake, Shin Sung Jae

机构信息

Animal Research Division, Seoul Zoo, Gwacheon 427-080, South Korea.

出版信息

J Zoo Wildl Med. 2011 Dec;42(4):743-6. doi: 10.1638/2010-0239.1.

Abstract

A disseminated infection caused by Mycobacterium avium subspecies avium (MAA) was diagnosed in a 57-yr-old male Asian elephant (Elephas maximus) housed at the Seoul Zoo, Gyeonggi, Republic of Korea. An apparent granulomatous inflammation with central caseous necrosis was evident in the lung sections. To confirm mycobacterial infection, polymerase chain reaction-restriction enzyme polymorphism analysis (PCR-RFLP) of the rpoB and hsp65 genes was performed from multiple organs and cultured bacteria. The PCR-RFLP revealed a M. avium subspecies. MAA was identified by multiplex PCR for detection of IS901 and IS1311. Thus, it is believed that MAA caused the disseminated infection in this case. Although the source of infection was not determined, the elephant may have become infected through contamination of soil and feed by free-living birds infected with MAA. This is the first reported case of disseminated infection due to MAA in a captive elephant in the Republic of Korea.

摘要

在韩国京畿道首尔动物园饲养的一头57岁雄性亚洲象(印度象)中,诊断出由鸟分枝杆菌鸟亚种(MAA)引起的播散性感染。在肺部切片中明显可见伴有中央干酪样坏死的明显肉芽肿性炎症。为了确诊分枝杆菌感染,从多个器官和培养的细菌中进行了rpoB和hsp65基因的聚合酶链反应-限制性酶切片段长度多态性分析(PCR-RFLP)。PCR-RFLP显示为鸟分枝杆菌亚种。通过多重PCR检测IS901和IS1311鉴定出MAA。因此,据信在该病例中是MAA引起了播散性感染。尽管感染源尚未确定,但这头大象可能是通过感染MAA的自由生活鸟类污染土壤和饲料而被感染的。这是韩国圈养大象中首例因MAA引起播散性感染的报告病例。

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