Khan N R, Khan G M, Wahab A, Khan A R, Hussain A, Nawaz A, Akhlaq M
Department of Pharmaceutics, Faculty of Pharmacy, Gomal University, D. I. Khan (Khyber Pakhtoonkhwa), Pakistan.
Pharmazie. 2011 Nov;66(11):849-52.
The aim of the present study was to investigate the transdermal permeation enhancing capability of turpentine oil for ibuprofen from hydrogels. Ibuprofen 1% w/v hydrogels were developed with carboxypolymethylene with and without turpentine oil. Turpentine oil was incorporated in increasing concentrations, i.e. 0.5, 1, 1.5, 2, 2.5 and 3% of the total gel formulation, and its permeation enhancing effect was examined. Gels were examined physically for pH, viscosity, spreadability, extrudability, smoothness and appearance. To study the in vitro and ex vivo permeation potential of formulated gels, permeation studies were performed with a Franz diffusion cell using cellulose membrane and excised rabbit abdominal skin. Ibuprofen hydrogel with 3% turpentine oil showed a maximum flux of 10.87 mg/cm2/h across artificial skin and 17.26 mg/cm2/h across rabbit abdominal skin.
本研究的目的是考察松节油对布洛芬从水凝胶中的透皮促进能力。采用羧甲基纤维素制备了含和不含松节油的1%（w/v）布洛芬水凝胶。以凝胶制剂总量的0.5%、1%、1.5%、2%、2.5%和3%的递增浓度加入松节油，并考察其促渗效果。对凝胶进行了pH值、粘度、铺展性、挤出性、光滑度和外观等物理性质的检测。为研究所制备凝胶的体外和离体渗透潜力，使用纤维素膜和切除的兔腹部皮肤，通过Franz扩散池进行渗透研究。含3%松节油的布洛芬水凝胶在人造皮肤上的最大通量为10.87mg/cm²/h，在兔腹部皮肤上的最大通量为17.26mg/cm²/h。
