Vascular Physiology Unit, Institute of Child Health, Great Ormond Street Hospital, London, WC1EH, UK.
Curr Pharm Des. 2011 Dec;17(37):4111-20. doi: 10.2174/138161211798764807.
Recent evidence suggests that patients with chronic inflammatory disorders are at increased cardiovascular risk. A number of different mechanisms have been postulated to contribute to atherosclerotic disease progression in these patients including traditional cardiovascular risk factors, cytokine upregulation, immume mediated pathways and increased oxidative stress. Novel treatments target inflammatory pathways and have beneficial effect on rheumatic disease activity however; their impact on cardiovascular risk reduction remains unclear. Further longitudinal studies are required to assess the value of different therapeutic approaches on cardiovascular outcome of these patients.
最近的证据表明，患有慢性炎症性疾病的患者心血管风险增加。有许多不同的机制被认为会导致这些患者的动脉粥样硬化疾病进展，包括传统的心血管危险因素、细胞因子上调、免疫介导途径和氧化应激增加。新型治疗方法针对炎症途径，对风湿性疾病活动有有益的影响；然而，它们对降低心血管风险的影响尚不清楚。需要进一步的纵向研究来评估不同治疗方法对这些患者心血管结局的价值。
