Cardiology Department, The Second Affiliated Hospital, Harbin Medical University , 246 Xue Fu Road, Harbin, China.
Scand Cardiovasc J. 2012 Apr;46(2):87-92. doi: 10.3109/14017431.2011.653823. Epub 2012 Jan 23.
The predictability of the whole-blood tissue factor levels for restenosis after coronary angioplasty is uncertain. We first probed in depth the association between plasma tissue factor concentrations and the development of restenosis after coronary intervention with an animal pathological model.
Thirty pigs were used and their coronary arteries were injured for the dilatation of balloons. Morphological measurements include neointimal area, injury score and the extent of area stenosis. Whole-blood tissue factor levels were measured before and after intervention. The circulating tissue factor levels increased significantly after intervention (baseline value, 328.54 ± 47.46 pg/ml; at 30th minute, 618.96 ± 119.08 pg/ml; at 24th hour, 639.34 ± 116.21 pg/ml) (p < 0.01), and the degrees of tissue factor changes correlated positively to the neointimal hyperplasty (r(30th min) = 0.751, r(24th hour) = 0.72, p < 0.01). There was no significant difference with the baseline whole blood tissue factor (TF) levels between restenotic and non-restenotic cases (330.83 ± 47.32 vs. 325.1 ± 49.57 pg/ml) (p > 0.05). The injury of media led to the most distinctive changes of blood tissue factor (p < 0.01).
Higher values of whole-blood tissue factor may be a predictor of restenosis, and the damaged media might be the main reason of the tissue factor increase.
全血组织因子水平对经皮冠状动脉成形术后再狭窄的预测性尚不确定。我们首先通过动物病理模型深入探讨了血浆组织因子浓度与经皮冠状动脉介入后再狭窄发展之间的关系。
使用 30 只猪，用球囊扩张其冠状动脉。形态学测量包括内膜面积、损伤评分和面积狭窄程度。在干预前后测量全血组织因子水平。干预后循环组织因子水平显著升高（基线值 328.54±47.46pg/ml；30 分钟时 618.96±119.08pg/ml；24 小时时 639.34±116.21pg/ml）（p<0.01），组织因子变化程度与内膜增生呈正相关（r（30 分钟）=0.751，r（24 小时）=0.72，p<0.01）。再狭窄组和非再狭窄组的基础全血组织因子（TF）水平无显著差异（330.83±47.32 vs. 325.1±49.57pg/ml）（p>0.05）。中膜损伤导致血液组织因子变化最显著（p<0.01）。
较高的全血组织因子值可能是再狭窄的预测因子，损伤的中膜可能是组织因子升高的主要原因。
