Internal Medicine Department, Mercy Hospital and Medical Center, 2525 South Michigan Ave Chicago, IL, USA.
Am J Emerg Med. 2012 Nov;30(9):2081.e1-2. doi: 10.1016/j.ajem.2011.10.024. Epub 2011 Dec 26.
Amiodarone is a widely used antiarrythmic drug for various atrial and ventricular arrhythmias. It has the potential to cause prolongation of the QT interval, which, in turn, can increases the incidence of torsade de pointes. Amiodarone is also one of the causes of prominent U waves. The presented case exemplifies the phenomenon of amiodarone-induced T-U fusion and QT prolongation. Other causes of QT prolongation as electrolyte abnormalities or administration of other drugs that prolong the QT interval were excluded. Awareness of this phenomenon and method of calculation of QT interval in this scenario is of utmost importance.
胺碘酮是一种广泛用于各种房性和室性心律失常的抗心律失常药物。它有延长 QT 间期的潜力,而 QT 间期的延长又会增加尖端扭转型室性心动过速的发生率。胺碘酮也是引起 U 波明显的原因之一。本病例举例说明了胺碘酮引起的 T-U 融合和 QT 间期延长现象。排除了其他导致 QT 间期延长的原因,如电解质异常或其他延长 QT 间期的药物。了解这种现象以及在这种情况下计算 QT 间期的方法至关重要。