Department of Chemistry, Inha University, Incheon, Republic of Korea.
Colloids Surf B Biointerfaces. 2012 Apr 1;92:240-5. doi: 10.1016/j.colsurfb.2011.11.048. Epub 2011 Dec 6.
Porous poly(ε-caprolactone) (PCL)/Eudragit RS 100 (ERS-100) microcapsules containing tulobuterol-adsorbed silica nanotubes (S-NTs) were prepared using a solvent evaporation method. The release behaviors of the PCL/ERS-100 microcapsules were investigated as a function of S-NT content. The PCL/ERS-100 microcapsules showed a stable and porous surface compared to the PCL microcapsules prepared without ERS-100. The drug loading and encapsulation efficiencies of the microcapsules were increased slightly by the addition of S-NTs due to the adsorption of the drugs on the S-NTs. In an acidic release medium, the PCL/ERS-100 microcapsules containing the tulobuterol-loaded S-NTs showed a slow drug release, which was dependent on the S-NT content. These behaviors are most likely due to the reduced diffusion rate of the drug from the hydrated microcapsules, which results from the strong interaction between the porous S-NTs and the drug.
多孔聚（ε-己内酯）（PCL）/Eudragit RS 100（ERS-100）载有妥洛特罗吸附二氧化硅纳米管（S-NTs）的微胶囊采用溶剂蒸发法制备。研究了 S-NT 含量对 PCL/ERS-100 微胶囊释放行为的影响。与未添加 ERS-100 制备的 PCL 微胶囊相比，PCL/ERS-100 微胶囊具有稳定且多孔的表面。由于药物吸附在 S-NTs 上，微胶囊的载药量和包封效率略有增加。在酸性释放介质中，载有妥洛特罗的 S-NTs 负载的 PCL/ERS-100 微胶囊表现出缓慢的药物释放，这取决于 S-NT 的含量。这些行为很可能是由于水合微胶囊中药物的扩散速率降低所致，这是由于多孔 S-NTs 与药物之间的强相互作用所致。
