Evidence-Based Medicine Center, Xuan Wu Hospital, Capital Medical University, No. 45 Changchun Street, Beijing 100053, China.
Arch Gerontol Geriatr. 2012 Nov-Dec;55(3):713-7. doi: 10.1016/j.archger.2011.12.001. Epub 2011 Dec 27.
This study aimed to investigate the influence of apoE genetic polymorphism on serum lipid changes in a community-based elderly population in China in an 8-year period, in which 746 individual, aged 65.29 ± 6.85 years (mean ± standard deviation (SD)) were enrolled and serum lipid parameters were checked at baseline. After 8 years, serum lipids as well as apoE genotypes were measured. The frequencies of apoE allele were 9.4%, 81.7%, and 8.9% for ɛ2, ɛ3 and ɛ4, respectively. After the population was divided into 3 groups by different apoE allele carriers, the apoE allele carriers for ɛ2, ɛ3 and ɛ4 were 121 (16.2%), 513 (68.8%) and 112 (15.0%), respectively. Levels of total cholesterol (TC) and low density lipoprotein (LDL) in ɛ2 carriers were lower comparing with that of ɛ3 allele carriers at baseline. 8 years later, TC and high density lipoprotein (HDL) elevated and LDL decreased with aging in this population (p<0.01). The changes of TC levels were smaller in ɛ2 allele carriers as compared to that of ɛ3 allele carriers. The difference was still statistically significant after controlling for age, sex, smoking status, drinking habit, body mass index (BMI) and baseline TC level. The same trend of changes was noted for LDL between ɛ2 and ɛ3 allele carriers. However, no significant differences were noted between ɛ4 and ɛ3 allele carriers on lipid changes. This community-based study shows that ɛ2 allele is helpful on lipid changes. The effect of ɛ4 allele on lipid change is not strong in this elderly population. Genetic and environmental factors maybe co-operate on lipid metabolism in elderly persons.
本研究旨在探讨载脂蛋白 E 基因多态性对中国社区老年人群 8 年期间血脂变化的影响，共纳入 746 名年龄为 65.29±6.85 岁（均值±标准差（SD））的个体，在基线时检查血脂参数。8 年后，检测了血清脂质和载脂蛋白 E 基因型。载脂蛋白 E 等位基因的频率分别为 ɛ2、ɛ3 和 ɛ4 的 9.4%、81.7%和 8.9%。将人群按照不同载脂蛋白 E 等位基因携带者分为 3 组后，ɛ2、ɛ3 和 ɛ4 载脂蛋白 E 等位基因携带者分别为 121 名（16.2%）、513 名（68.8%）和 112 名（15.0%）。在基线时，ɛ2 携带者的总胆固醇（TC）和低密度脂蛋白（LDL）水平低于 ɛ3 等位基因携带者。8 年后，随着人群的老化，TC 和高密度脂蛋白（HDL）升高，LDL 降低（p<0.01）。与 ɛ3 等位基因携带者相比，ɛ2 等位基因携带者的 TC 水平变化较小。在控制年龄、性别、吸烟状况、饮酒习惯、体重指数（BMI）和基线 TC 水平后，差异仍具有统计学意义。在 ɛ2 和 ɛ3 等位基因携带者之间，LDL 的变化趋势也相同。然而，在血脂变化方面，ɛ4 和 ɛ3 等位基因携带者之间没有显著差异。这项基于社区的研究表明，ɛ2 等位基因有助于血脂变化。在该老年人群中，ɛ4 等位基因对血脂变化的影响并不强烈。遗传和环境因素可能共同影响老年人的脂质代谢。
