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E2与低密度脂蛋白与中国老年精神分裂症住院患者抑郁症状的关联：一项横断面研究。

Association of E2 and low-density lipoprotein with depressive symptoms in Chinese senile schizophrenia inpatients: A cross-sectional study.

作者信息

Li Wei

机构信息

Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Alzheimer's Disease and Related Disorders Center, Shanghai Jiao Tong University, Shanghai, China.

出版信息

Schizophr Res Cogn. 2020 Nov 19;23:100193. doi: 10.1016/j.scog.2020.100193. eCollection 2021 Mar.

DOI:10.1016/j.scog.2020.100193
PMID:33294393
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7689319/
Abstract

BACKGROUND

Schizophrenia is considered to occur due to both environmental and genetic factors. Depressive symptoms and apolipoprotein E () gene polymorphisms are involved in the pathogenesis of schizophrenia. However, the effect of gene polymorphism on depressive symptoms has never been investigated among Chinese elderly schizophrenia patients.

OBJECTIVE

This cross-sectional study aimed to determine the effect of gene polymorphism on blood lipid metabolism and depressive symptoms among elderly schizophrenia patients.

METHOD

A total of 301 elderly schizophrenia patients (161 males, age ranges from 60 to 92 years, with an average age of 67.31 ± 6.667) were included in the study. Depressive symptoms were assessed using the Geriatric Depression Scale (GDS). gene polymorphisms were determined by polymerase chain reaction (PCR). Correlations between GDS and serum low-density lipoprotein (LDL) levels with genotypes were assessed.

RESULTS

The concentration of LDL in the E2 group was significantly lower than those in the E3 and E4 groups, and the GDS scores in the E2 and E3 groups were higher than those in the E4 group. Using partial correlation analysis and controlling the duration of disease and hyperlipidemia, we found that GDS scores were significantly correlated with LDL ( = -0.179,  = 0.025).

CONCLUSIONS

E2 genotype is associated with more depressive symptoms and lower serum LDL in elderly Chinese schizophrenia patients, and there is a negative correlation between depressive symptoms and LDL.

摘要

背景

精神分裂症被认为是由环境和遗传因素共同导致的。抑郁症状和载脂蛋白E（）基因多态性参与了精神分裂症的发病机制。然而，在中国老年精神分裂症患者中，基因多态性对抑郁症状的影响尚未得到研究。

目的

这项横断面研究旨在确定基因多态性对老年精神分裂症患者血脂代谢和抑郁症状的影响。

方法

本研究共纳入301例老年精神分裂症患者（161例男性，年龄范围为60至92岁，平均年龄为67.31±6.667）。使用老年抑郁量表（GDS）评估抑郁症状。通过聚合酶链反应（PCR）确定基因多态性。评估GDS与血清低密度脂蛋白（LDL）水平与基因型之间的相关性。

结果

E2组的LDL浓度显著低于E3组和E4组，E2组和E3组的GDS评分高于E4组。通过偏相关分析并控制病程和高脂血症，我们发现GDS评分与LDL显著相关（= -0.179，= 0.025）。

结论

在中国老年精神分裂症患者中，E2基因型与更多的抑郁症状和更低的血清LDL相关，且抑郁症状与LDL之间存在负相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1887/7689319/e117c60013d1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1887/7689319/9b02f63b1bdb/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1887/7689319/e117c60013d1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1887/7689319/9b02f63b1bdb/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1887/7689319/e117c60013d1/gr2.jpg

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