Department of Cardiology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey.
Med Sci Monit. 2012 Jan;18(1):CR25-31. doi: 10.12659/msm.882197.
Cardiotrophin-1 (CT-1) is a member of the interleukin (IL-6) family of cytokines and is increased in various cardiovascular diseases, including chronic heart failure. The aim of the study was to determine if plasma CT-1 is associated with diastolic heart failure (DHF) and to investigate the relationship between CT-1 and echocardiographic parameters.
MATERIAL/METHODS: Fifty-seven consecutive patients (mean age 57 ± 8 years, 24 males) diagnosed with DHF in our clinic and 33 controls (mean age 55 ± 7 years, 12 males) were included in the study. All study participants underwent echocardiographic evaluation and blood samples were obtained.
CT-1 and NT-proBNP values were significantly higher in DHF subjects than in controls (11.30 [8.09-16.51] vs. 17.5 [8.95-28.74] fmol/mL, P=0.017 and 64 [27.5-95] vs. 82 [55.5-241] pg/mL, P=0.009, respectively). The mitral peak velocity of early diastolic filling (E), mean ratio of E to early diastolic mitral annular velocity (E/Em), and the pulmonary capillary wedge pressure (PCWP) estimated from E/Em measurements were all significantly higher in the patient group (62.27 ± 14.69 vs. 75.67 ± 18.85 cm/sec, 6.40 ± 1.48 vs. 10.30 ± 3.48, and 10 [9-11] vs. 14[12-16] mmHg, P ≤ 0.001 for all). Lateral and septal Em were significantly lower in the patient group (10.69 ± 1.87 vs. 8.69 ± 2.00 cm/sec and 8.91 ± 1.22 vs. 6.65 ± 1.58 cm/sec, P<0.001 for both). CT-1 positively correlated with NT-proBNP (P=0.001, r=0.349), mean E/Em (P=0.003, r=0.307), and estimated mean PCWP (P=0.001, r=0.308).
CT-1 is elevated in patients with DHF and is associated with NT-proBNP and estimated left ventricular filling pressures.
心营养素-1（CT-1）是白细胞介素（IL-6）家族细胞因子的成员，在各种心血管疾病中增加，包括慢性心力衰竭。本研究的目的是确定血浆 CT-1 是否与舒张性心力衰竭（DHF）相关，并研究 CT-1 与超声心动图参数之间的关系。
材料/方法：本研究纳入了 57 例连续在我院就诊的 DHF 患者（平均年龄 57 ± 8 岁，24 名男性）和 33 名对照者（平均年龄 55 ± 7 岁，12 名男性）。所有研究参与者均接受了超声心动图评估，并采集了血液样本。
与对照组相比，DHF 患者的 CT-1 和 NT-proBNP 值明显更高（11.30[8.09-16.51] vs. 17.5[8.95-28.74] fmol/mL，P=0.017 和 64[27.5-95] vs. 82[55.5-241] pg/mL，P=0.009）。E 峰的二尖瓣早期舒张充盈速度（E）、E 与二尖瓣环早期舒张速度比值（E/Em）的平均值和通过 E/Em 测量估计的肺毛细血管楔压（PCWP）在患者组中均明显更高（62.27 ± 14.69 vs. 75.67 ± 18.85 cm/sec，6.40 ± 1.48 vs. 10.30 ± 3.48，10[9-11] vs. 14[12-16]mmHg，P≤0.001）。患者组的侧壁和间隔 Em 明显更低（10.69 ± 1.87 vs. 8.69 ± 2.00 cm/sec 和 8.91 ± 1.22 vs. 6.65 ± 1.58 cm/sec，P<0.001）。CT-1 与 NT-proBNP（P=0.001，r=0.349）、平均 E/Em（P=0.003，r=0.307）和估计的平均 PCWP（P=0.001，r=0.308）呈正相关。
CT-1 在 DHF 患者中升高，与 NT-proBNP 和估计的左心室充盈压相关。
