Stejskal David, Ruzicka Viktor
Department of Laboratory Medicine, Sternberk Hospital, Czech Republic.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2008 Jun;152(1):9-19. doi: 10.5507/bp.2008.002.
Cardiotrophin-1 is newly discovered chemokin with a lot of functions. Aim of our work was to describe most important of them.
systematically scan of available scientific resources.
Cardiotrophin-1 stimulates the proliferation of cardiomyocytes. Cardiotrophin-1 expression and plasma values are elevated in individuals with heart failure and have high diagnostic efficacy for the heart failure. Plasma values are also an independent prognostic factor. Preliminary findings suggest that the determination of plasma cardiotrophin-1 may be useful for the follow-up of hypertensive heart disease in routine clinical practice. Cardiotrophin-1 also plays an important cardioprotective effect on myocardial damage, is a potent regulator of signaling in adipocytes in vitro and in vivo and potentiates the elevation the acute-phase proteins. Cardiotrophin-1 may play also an important protective role in other organ systems (such as hematopoietic, neuronal, developmental).
Cardiotrophin is a newly discovered chemokin with a lot of system effects and is stable in system circulation hence permitting its development in the routine clinical investigation.
心肌营养素-1是新发现的具有多种功能的趋化因子。我们研究的目的是描述其最重要的功能。
系统检索现有科学资源。
心肌营养素-1可刺激心肌细胞增殖。心力衰竭患者的心肌营养素-1表达及血浆水平升高，对心力衰竭具有较高的诊断效能。血浆水平也是一个独立的预后因素。初步研究结果表明，在常规临床实践中，测定血浆心肌营养素-1可能有助于高血压性心脏病的随访。心肌营养素-1对心肌损伤也具有重要的心脏保护作用，在体外和体内均是脂肪细胞信号传导的有效调节因子，并能增强急性期蛋白的升高。心肌营养素-1在其他器官系统（如造血、神经、发育）中可能也发挥重要的保护作用。
心肌营养素是一种新发现的具有多种系统效应的趋化因子，在体循环中稳定，因此可用于常规临床研究。
