Kaçar Ayper, Paker Irem, Akbiyik Fatih, Arikök Ata Türker, Mambet Ervin
Department of Pediatric Pathology, Ankara Children's Hematology and Oncology Hospital, Ankara, Turkey.
Turk Patoloji Derg. 2012;28(1):31-7. doi: 10.5146/tjpath.2012.01094.
CD117 and CD34 are markers that have both been implied in cancer progression in adult breast lesions. This study was conducted in order to create a retrospective documentation and to analyze the expression patterns of these markers on childhood benign lesions along with a comparison with adult breast lesions' staining patterns.
Nine fibroadenomas, 2 tubular adenomas, 1 mammary hamartoma, 2 gynecomastias, 1 benign phyllodes tumor were retrieved from pathology archives of two reference centers between 2005-2010.
CD117 staining was identified in the epithelium of all cases in fibroadenoma/tubular adenoma group and focally positive in 1 mammary hamartoma, 2 gynecomastias, and 1 benign phyllodes tumor. CD117 staining was detected in the stroma of 8 cases. Three fibroadenomas, 1 mammary hamartoma, 2 gynecomastias and 1 benign phyllodes tumor lacked stromal labelling for this marker. All cases were strongly and diffusely positive for CD34 except the benign phyllodes tumor case. This case presented marked loss of stromal CD34 staining when compared to the surrounding stroma. Additionally, pseudoangiomatous stromal hyperplasia was noted in 2 gynecomastias and in the peritumoral stroma of benign phyllodes tumor case.
Our study demonstrated that fibroadenoma was the most commonly encountered breast lesion in childhood and that adolescent fibroadenomas showed similar staining patterns for CD117 and CD34 as for adult counterparts. On the other hand, different expression patterns of CD117 and CD34 between adenoma group and the gynecomastias and benign phyllodes tumor group may implicate different mechanisms of development and tumorigenesis among these groups.
CD117和CD34是与成人乳腺病变癌症进展相关的标志物。本研究旨在进行回顾性记录，并分析这些标志物在儿童良性病变中的表达模式，同时与成人乳腺病变的染色模式进行比较。
2005年至2010年间，从两个参考中心的病理档案中检索出9例纤维腺瘤、2例管状腺瘤、1例乳腺错构瘤、2例男性乳腺增生症、1例良性叶状肿瘤。
纤维腺瘤/管状腺瘤组所有病例的上皮细胞中均检测到CD117染色，1例乳腺错构瘤、2例男性乳腺增生症和1例良性叶状肿瘤呈局灶性阳性。8例病例的间质中检测到CD117染色。3例纤维腺瘤、1例乳腺错构瘤、2例男性乳腺增生症和1例良性叶状肿瘤该标志物的间质标记缺失。除良性叶状肿瘤病例外，所有病例的CD34均呈强阳性且弥漫性阳性。与周围间质相比，该病例的间质CD34染色明显缺失。此外，在2例男性乳腺增生症和良性叶状肿瘤病例的肿瘤周围间质中发现了假血管瘤样间质增生。
我们的研究表明，纤维腺瘤是儿童期最常见的乳腺病变，青少年纤维腺瘤的CD117和CD34染色模式与成人相似。另一方面，腺瘤组与男性乳腺增生症和良性叶状肿瘤组之间CD117和CD34的表达模式不同，可能意味着这些组之间存在不同的发育和肿瘤发生机制。
