Rizzo G, Nicolaides K H, Arduini D, Campbell S
Department of Obstetrics and Gynecology, Università Cattolica S. Cuore, Roma, Italy.
Am J Obstet Gynecol. 1990 Oct;163(4 Pt 1):1231-8. doi: 10.1016/0002-9378(90)90696-5.
In 12 fetuses from pregnancies with red blood cell isoimmunization Doppler velocity waveforms were recorded at the level of atrioventricular valves immediately before and at 15-minute intervals for 2 hours after the intravascular transfusion. The left and right cardiac outputs, the ratio between the peak velocities during early passive ventricular filling and active atrial filling at the level of both ventricles as well as the heart rate were calculated. Before transfusion, the left and right cardiac outputs were significantly higher than reference ranges for gestation that were constructed from the cross-sectional study of 187 normal pregnancies. After transfusion there was a significant temporary fall in right and left outputs associated with increased ratios between the peak velocities during early passive ventricular filling and active atrial filling. Within 2 hours after transfusion both parameters returned toward the normal range. In addition, no significant changes were found for fetal heart rate values before and after transfusion. The fall of cardiac output was significantly related to the amount of expansion of the feto-placental volume.
在12例患有红细胞同种免疫的胎儿妊娠中，在血管内输血前以及输血后2小时内，每隔15分钟在房室瓣水平记录多普勒速度波形。计算左右心输出量、心室早期被动充盈和心房主动充盈时两心室水平的峰值速度之比以及心率。输血前，左右心输出量显著高于根据187例正常妊娠的横断面研究构建的妊娠参考范围。输血后，左右心输出量出现显著的暂时下降，同时早期被动心室充盈和心房主动充盈时的峰值速度之比增加。输血后2小时内，这两个参数均恢复至正常范围。此外，输血前后胎儿心率值未发现显著变化。心输出量的下降与胎儿-胎盘体积的扩张量显著相关。
