Department of Orthopaedics and Traumatology, North-Kymi Hospital, FI-45750 Kuusankoski, Finland.
Arch Gerontol Geriatr. 2012 May-Jun;54(3):e294-9. doi: 10.1016/j.archger.2011.12.002. Epub 2011 Dec 28.
To analyze the type and effect of prior and subsequent fractures in a hip fracture cohort.
Hip fracture patients (n=221) were followed for a mean of 8 years and all prior and subsequent fractures were studied. Incidence of the first fracture and subsequent fractures according to sex, age group, and time between the first and the index hip fracture were measured. The absolute fracture risk was measured in the study subjects and in the age groups <75 years and ≥75 years. Patients' survival was analyzed with the life-table method.
One third of the hip fracture patients had sustained previous fractures. In men, these were mostly ankle or hip fractures, and in women, wrist fractures. Of the subjects, 24% suffered a subsequent fracture, which in both sexes was usually a second hip fracture. At the end of the 8-year follow-up, 74% of the patients had died. The observed absolute fracture risk was 7% at one year and 24% at 5 years. In women, excess mortality was lowest during the first 4.8 years after the index hip fracture among patients with one fracture. However, it was highest among women with two fractures. In men, excess mortality was lowest among those with two fractures and highest among those with ≥3 fractures. There were no differences between the genders in sustaining subsequent fractures.
The fracture risk subsequent to hip fracture was similar in both genders. Patients with prior hip fractures had the worst survival rate.
分析髋部骨折队列中既往和后继骨折的类型和影响。
对 221 例髋部骨折患者进行了平均 8 年的随访,并对所有既往和后继骨折进行了研究。测量了首次骨折和后继骨折的发生率,按性别、年龄组和首次与索引髋部骨折之间的时间进行分组。在研究对象和<75 岁和≥75 岁年龄组中测量绝对骨折风险。用寿命表法分析患者的生存情况。
三分之一的髋部骨折患者既往有骨折。男性既往骨折多为踝关节或髋部骨折,女性多为腕部骨折。24%的患者发生了后继骨折,男女均为第二次髋部骨折。在 8 年的随访结束时,74%的患者已经死亡。观察到的 1 年绝对骨折风险为 7%,5 年时为 24%。在女性中,首次髋部骨折后 4.8 年内,有一次骨折的患者的超额死亡率最低。然而,有两次骨折的女性的超额死亡率最高。在男性中,有两次及以上骨折的患者的超额死亡率最低,有三次及以上骨折的患者的超额死亡率最高。在发生后继骨折方面,男女之间没有差异。
髋部骨折后继发骨折的风险在两性中相似。有既往髋部骨折的患者生存率最差。