Ruby A J, Jampol L M
Department of Ophthalmology, Northwestern University Medical School, Chicago, Illinois 60611.
Am J Ophthalmol. 1990 Oct 15;110(4):349-53. doi: 10.1016/s0002-9394(14)77013-8.
Patients with Crohn's disease may manifest extraintestinal findings including ocular involvement. We treated two patients with Crohn's disease who manifested retinal vascular disease that may have been related to the immune nature of the underlying disease or possibly to changes in the vasculature or coagulation system. One patient had a central retinal vein occlusion and the other had retinal vasculitis involving retinal arteries and veins with an apparent branch retinal artery occlusion. Both patients were in excellent health except for Crohn's disease, which was confirmed by a biopsy specimen. In one patient, the diagnosis of retinal vasculitis preceded the clinical diagnosis of Crohn's disease, whereas for the second patient the symptomatology of the intestinal disease preceded the ocular manifestations. We suggest that inflammatory bowel disease should be considered in the differential diagnosis of retinal vascular occlusive disease, especially in a young patient.
克罗恩病患者可能出现包括眼部受累在内的肠外表现。我们治疗了两名患有克罗恩病的患者，他们表现出视网膜血管疾病，这可能与潜在疾病的免疫性质有关，也可能与血管系统或凝血系统的变化有关。一名患者发生视网膜中央静脉阻塞，另一名患者患有视网膜血管炎，累及视网膜动脉和静脉，并伴有明显的视网膜分支动脉阻塞。除经活检标本证实的克罗恩病外，两名患者的身体状况均良好。在一名患者中，视网膜血管炎的诊断先于克罗恩病的临床诊断，而在另一名患者中，肠道疾病的症状先于眼部表现。我们建议，在视网膜血管闭塞性疾病的鉴别诊断中应考虑炎性肠病，尤其是在年轻患者中。
