Pôle de recherche en Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium.
Clin Biochem. 2012 Feb;45(3):249-52. doi: 10.1016/j.clinbiochem.2011.12.009. Epub 2011 Dec 20.
B-type natriuretic peptide (BNP) and amino-terminal proBNP (Nt-proBNP) are derived from a common precursor, the proBNP(1-108) (proBNP), synthesized by cardiomyocytes. We determined proBNP concentrations in patients admitted to ED and suspected of CHF.
One hundred fifty six consecutive patients admitted to ED were included. ProBNP, BNP and Nt-proBNP levels were determined at admission.
In this ED population, assays for proBNP, BNP and Nt-proBNP were positively and significantly correlated. Circulating levels of proBNP were higher in patients admitted to ED for CHF than in patients admitted to ED other reasons. Applying receiver operating characteristic curve (ROC) analysis for the diagnosis of CHF, the area under the curve (AUC) was 0.92 for proBNP.
Our study demonstrated that proBNP testing, the precursor of BNP and Nt-proBNP, appears as a relevant tool to assist the diagnosis of CHF in patients admitted to ED.
B 型利钠肽（BNP）和氨基末端 proBNP（Nt-proBNP）来源于共同的前体，即由心肌细胞合成的 proBNP（1-108）（proBNP）。我们测定了因疑似充血性心力衰竭（CHF）而收入急诊部（ED）的患者的 proBNP 浓度。
共纳入 156 例连续收入 ED 的患者。在入院时测定 proBNP、BNP 和 Nt-proBNP 水平。
在 ED 人群中，proBNP、BNP 和 Nt-proBNP 的检测结果呈正相关且显著相关。因 CHF 收入 ED 的患者的循环 proBNP 水平高于因其他原因收入 ED 的患者。应用 ROC 分析 proBNP 对 CHF 的诊断价值，曲线下面积（AUC）为 0.92。
我们的研究表明，proBNP 检测，即 BNP 和 Nt-proBNP 的前体，似乎是一种有助于诊断 ED 患者 CHF 的相关工具。
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